Disturbances in Tryptophan Metabolism Following Chronic Ingestion of a High Copper Diet by Male Rats

  • L. Bruce Weekley
  • T. D. Kimbrough
  • Charles E. O’Rear
  • Gerald C. Llewellyn
Part of the Biodeterioration Research book series (BIOR, volume 4)

Abstract

Copper (Cu) is required in the diet as a trace mineral to prevent hypochromic microcytic anemia secondary to defective hemoglobin synthesis (Hart et al., 1928). This metal is also required for the normal function of a number of oxidative enzymes including catalase, peroxidase, and cytochrome oxidase. Following absorption from the gastrointestinal tract, copper is weakly bound to albumin and later more firmly bound to ceruloplasim, a specific Cu transport protein (Linder and Moor, 1977). Bile is the normal excretory route for copper and plays a primary role in copper homeostasis while liver and bone normally store excess copper.

Keywords

Biogenic Amine Kynurenic Acid Copper Acetate Copper Homeostasis Hypochromic Microcytic Anemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Agnese, T., Vreis, B., and Stanolini, B. (1959). Incidence of lung cancer in relation to occupation in Genoa. Ind. Hygiene Mod. 52: 149–160.Google Scholar
  2. Ansell, G., and Beeson, M. (1968). A rapid and sensitive procedure for the combined assay of norepinephrine, dopamine and serotonin in a single brain sample. Analyt. Biochem. 23:196–206.Google Scholar
  3. Arnold, M., and Sasse, D. (1961). Quantitative and histochemical analysis of Cu, Zn and Fe in spontaneous and induced primary tumors of rats. Cancer Res. 21: 761–766.Google Scholar
  4. Billiwicz, W.Z., Kemsley, W.F., and Thomson, A.M. (1962). Indices of adiposity. Brit. J. Prey. Soc. Med. 16: 183–188.Google Scholar
  5. Brady, F.O., Monaco, M.E., and Forman, H.J. (1972). On the role of copper in activation of and catalysis by tryptophan 2, 3 dioxygenase. J. Biol. Chem. 247: 7915–7922.Google Scholar
  6. Centers for Disease Control (1975). Acute copper poisoning. Morb. Mort. Week. Rep. Mar. 15:99.Google Scholar
  7. Chuttani, H.K., Gt. Gupti, P.S., and Gultati, S. (1965) Acute copper sulfate poinsoning. Amer. J. Med. 39: 849–854.Google Scholar
  8. Doumas, B.T., Waxton, W.A., and Biggs, H.C. (1971). Albumin standards and the measurement of serum albumin with bromcresol green. Clin. Chem. Acta. 31:87–96.Google Scholar
  9. Fare, G. (1965). Copper acetate as an accelerator in mouse skin carcinogenesis by 9, 10 dimethyl-12-benzanthracene. Experientia. 21: 415–416.Google Scholar
  10. Fare, G., and Woodhouse, D.L. (1963). The distribution of copper in the tissues of the rat: The effects of age and of feeding with Pdimethylaminoazobenzene with and without copper acetate. Br. J. Cancer 17: 775–786.Google Scholar
  11. Gilman, J.P., and Ruckenbauer, G.M. (1962). Metal carcinogensis: Observations on the carcinogenicity of a refinery dust cobalt oxide and ollodial thorium oxide. Cancer Res. 22: 152–157.Google Scholar
  12. Gray, L.F., and Daniel, L.J. (1973). Effect of copper status on the urinary excretion of tryptophan metabolities and amino acids by the rat. J. Nutr. 103: 1764–1771.Google Scholar
  13. Hansen, L.G., and Warwick, W.J. (1969). A fluorometric micromethod for serum Vitamins A and E. Ameri. J. Clin. Natr. 51:538–541.Google Scholar
  14. Harman, D. (1965). The free radical theory of aging. Effect of age on serum copper levels. J. Gerontol. 20: 151–153.CrossRefGoogle Scholar
  15. Hart, E.B., Steenbock, H., Waddell, J., and Elvehjem, C.A. (1928). Iron in nutrition: Copper as a supplement to iron for hemoglobin building in the rat. J. Biol. Chem. 77: 797–800.Google Scholar
  16. Kingsbury, J.M. (1975). Toxicology the basic science of poisons. L. Casarett and J. Powell, ed. Macmillan Pub. New York, NY, pp. 591–603.Google Scholar
  17. Knox, W.E. (1966). Hormonal control of tryptophan pyrrolase. Adv. Enz. Regl. 4: 287–297.CrossRefGoogle Scholar
  18. Linder, M.C., and Moor, J.C. (1977). Plasma ceruloplasmin: Evidence for its presence in and uptake by heart and other organs of the rat. Biochm. Biophvs. Acta. 499:329–366.Google Scholar
  19. Luckey, T.D., and Venugopal, B. (1977). Metal toxicity in mammals-1: Physiologic and chemical basis for metal toxicity. Plenum Press, Neqw York, NY, pp. 166.CrossRefGoogle Scholar
  20. Maickel, R.P., Cox, R.H., Saillant, J., and Miller, F.P. (1968). A method for the determination of serotonin and norepinephrine in discrete areas of rat brain. Int. J. Neuropharmacol. 7: 275–281.CrossRefGoogle Scholar
  21. Ness, A.T., Pastewka, J.V., and Peacock, A.C. (1964). Evaluation of a recently reported stable Liebermann-Burchard Reagent and its use for the direct determination of serum total cholesterol. Clin. Chem. Acta. 10:229–237.Google Scholar
  22. Pallidini, G., Venturini, A., and Conforti, A. (1977). Copper and the nervous system: An experimental study. Path. Biol. 25:299–306.Google Scholar
  23. Petering, H.G., Lalitha, M., and O’Flaherty, E. (1977). Influence of dietary zinc and copper on rat lipid metabolism. J. Aar. Food Chem. 25: 1105–1109.CrossRefGoogle Scholar
  24. Schroeder, H.A., Nason, A., Tipton, A., and Balassa, J.J. (1966). Essential trace metals in man: Copper. J. Chronic Dis. 19: 1007–1034.CrossRefGoogle Scholar
  25. Stanton, M.F. (1967). Primary tumors of bone and lungs in rats following local deposition of copper chelated N-hydroxy-2-acetylaminofluorene. Cancer Res. 28: 1000.Google Scholar
  26. Stocks, P., and Davies, R.I. (1960). Epidemiological evidence from chemical and spectrographic analysis that soil is concerned in the causation of cancer. Br. J. Cancer 14: 8–22.CrossRefGoogle Scholar
  27. Suttle, N.F., and Mills, C.F. (1966). Studies on the toxicity of copper to pigs. Br. J. Nutr. 20: 135–140.CrossRefGoogle Scholar
  28. West, S.W., Todd, W.F., and Mason, H.S. (1970). Textbook of Biochemistry. MacMillan Co. Toronto, Canada, pp. 1023.Google Scholar
  29. Williams, A.O. (1965). Studies on copper, ceruloplamsin and cirrhosis in relation to Wilsons Disease. Brit. J. Exp. Pathol. 46:564–568.Google Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • L. Bruce Weekley
    • 1
    • 2
  • T. D. Kimbrough
    • 3
  • Charles E. O’Rear
    • 4
  • Gerald C. Llewellyn
    • 5
    • 6
  1. 1.College of Veterinary MedicineVirginia Polytechnic and State UniversityBlacksburgUSA
  2. 2.Department of Veterinary ScienceColorado State UniversityFort CollinsUSA
  3. 3.Department of BiologyVirginia Commonwealth UniversityRichmondUSA
  4. 4.Department of Forensic ScienceThe George Washington UniversityUSA
  5. 5.Department of Forensic ScienceThe George Washington UniversityUSA
  6. 6.Delaware Department of Natural Resources and Environmental ControlNew CastleUSA

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