Assay of Nitroglycerin and Metabolites by Capillary GC
Satisfactory procedures are needed for the assay in plasma of nitroglycerin (glyceryl trinitrate, GTN) and denitrated metabolites, two isomeric dinitroglycerols (1,2- and 1,3-GDN) and mononitroglycerol (GMN; 2 isomers). Besides glycerol itself, metabolism also furnishes inorganic nitrite and, therefrom by reaction with GSH (forming GSSG), nitrate; the desirability of being able to measure these 4 analytes was pointed out at the 1985 Bioanalytical Forum (, wherein p. 111 shows metabolic pathways) but is not pursued here.
KeywordsPacked Column Forensic Context Satisfactory Procedure Miller Health Thermal Energy Analyzer
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