Variations in the Metabolism of Peptidoglycan Prior to Polymerization

  • Jean van Heijenoort
  • Dominique Mengin-Lecreulx
  • Yveline van Heijenoort
  • Didier Blanot
  • Bernard Flouret
  • Catherine Michaud
  • Claudine Parquet
  • Flore Pratviel-Sosa
  • Manolo Gomez
  • Juan A. Ayala
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 65)

Abstract

The biosynthesis of bacterial cell wall peptidoglycan is a complex process which comprises two major stages (Rogers et al., 1980). The first one concerns the sequential formation of a series of cytoplasmic and membrane precursors. The second one concerns the polymerisation reactions with the insertion of the new peptidoglycan material and its maturation. The first stage of peptidoglycan synthesis is considered to begin with UDP-N-acetylglucosamine (UDP-GlcNAc) and to end with N-acetylglucosaminyl-N-acetylmuramyl (pentapeptide) -pyrophosphate undecaprenol (lipid II in Fig.1) which is the substrate for the polymerization reactions. The different steps prior to polymerization have long been identified and certain studied to some extent (Rogers et al., 1980). However little attention had been paid to their in vivo functioning.

Keywords

Uridine Diphosphate Pool Level Diaminopimelic Acid Peptidoglycan Synthesis Nucleotide Precursor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Jean van Heijenoort
    • 1
  • Dominique Mengin-Lecreulx
    • 1
  • Yveline van Heijenoort
    • 1
  • Didier Blanot
    • 1
  • Bernard Flouret
    • 1
  • Catherine Michaud
    • 1
  • Claudine Parquet
    • 1
  • Flore Pratviel-Sosa
    • 1
  • Manolo Gomez
    • 2
  • Juan A. Ayala
    • 2
  1. 1.URA 1131 du C.N.R.S.Université Paris-SudOrsay CedexFrance
  2. 2.Centro de Biologia MolecularUniversidad Autonoma de MadridMadridSpain

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