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Human Immunodeficiency Virus Variation and Epidemiology of Acquired Immunodeficiency Syndrome and Human Immunodeficiency Virus Infection

  • Mary E. Chamberland
  • James W. Curran
Part of the Applied Virology Research book series (AVIR, volume 2)

Abstract

Substantial progress has been achieved during the last few years in elucidating a clearer understanding of the molecular biology of human immunodeficiency virus-1 (HIV-1) and its mechanisms of infectivity and pathogenesis. HIV-1 selectively infects cells that have a surface antigen known as CD4 (Klatzmann et al., 1984; Maddon et al., 1986). The T-helper lymphocyte is particularly susceptible; infection with HIV-1 can destroy T-helper cells and interfere with T-helper cell function (Barre-Sinoussi et al., 1983; Gallo, et al., 1984; Fauci, 1988). CD4-positive monocytes, macrophages, B lymphocytes, and certain cells in the brain and gastrointestinal tract can also be infected with HIV- I (Montagnier et al., 1984; Gartner et al., 1986; Wiley et al., 1986; Nelson et al., 1988). The collective result is profound immunosuppression manifested by opportunistic infections and malignancies, as well as other clinical features including hematologic abnormalities, arthritis, pneumonitis, nephritis, certain diarrhea’ and wasting syndromes, and neurologie dysfunction, all of which may be direct viral effects rather than secondary effects of immune suppression (Report of the Workgroup on Clinical Manifestations and Pathogenesis, 1989).

Keywords

Social Affair Heterosexual Transmission Indicator Disease Heterosexual Contact Opportunistic Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Mary E. Chamberland
    • 1
  • James W. Curran
    • 1
  1. 1.Division of HIV/AIDSCenter for Infectious Diseases, Centers for Disease Control, Public Health Service, U.S. Department of Health and Human ServicesAtlantaUSA

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