Methods for the Radiohalogenation of Antibodies
One of the main goals of radiopharmaceutical chemistry is the development of compounds that can be used for the identification or erradication of specific cell populations. Since monoclonal antibodies (MAbs) can be generated, at least in principle, against almost any cellular determinant, there has been a great deal of interest in using MAbs as a mechanism for targeting radionuclides. Although diagnostic and therapeutic investigations with labeled MAbs have focused on their applications in the management of cancer, labeled MAbs also may be useful in the noninvasive diagnosis of infections and heart disease. Numerous problems must be solved before radiolabeled MAbs can make a meaningful impact on the clinical domain, including the development of better MAb labeling methods than those that have been utilized in clinical studies.
KeywordsAlpha Particle Linear Energy Transfer Label Protein Thyroid Uptake Positron Emission Tomogra
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