P1GF: Placenta Derived Growth Factor

  • Domenico Maglione
  • Maria Graziella Persico
Chapter
Part of the NATO ASI Series book series (NSSA, volume 263)

Abstract

The formation of new blood vessels from pre-existing ones, a phenomenon called angiogenesis, is a complicated process that involves the migration, proliferation and organization of endothelial cells. Angiogenesis is virtually absent in the healthy adult organism, restricted to a few conditions including wound healing and the formation of corpo luteum, endometrium, and placenta. In contrast, in certain pathological conditions, angiogenesis is dramatically enhanced, for example, in rheumatoid arthritis, psoriasis, diabetic retinopathy, hemangiomas and in solid tumors (Folkman and Klagsbrun, 1987; Klagsbrun and D’Amore, 1991).

Keywords

Vascular Endothelial Growth Factor Human Placenta Vascular Permeability Factor VEGF Gene Amino Acid Stretch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Domenico Maglione
    • 1
  • Maria Graziella Persico
    • 2
  1. 1.Geymonat SpA Pharmaceutical industryAnagni (FR)Italy
  2. 2.International Institute of Genetics and BiophysicsCNRNaplesItaly

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