Angiogenesis pp 219-231 | Cite as

Hyaluronan and Angiogenesis: Molecular Mechanisms and Clinical Applications

  • S. Kumar
  • J. Ponting
  • P. Rooney
  • P. Kumar
  • D. Pye
  • M. Wang
Chapter
Part of the NATO ASI Series book series (NSSA, volume 263)

Abstract

The extracellular matrix (ECM) is found in contact with most cells of a multicellular organism and can be thought of as an extension of the cell surface. It provides mechanical support for cells, may act as a reservoir for growth factors, is the environment through which nutrients are passed and, by virtue of the fact that many of its constituents interact with each other and with the cell surface via specific receptors, it can affect and participate in functions of the cell including adhesion, migration, proliferation, differentiation and gene regulation (Hay, 1991; Rooney and Kumar 1993). A major and important component of the ECM is hyaluronic acid (HA, also known as hyaluronan and hyaluronate). HA plays many roles (Table 1); in particular we have shown that in angiogenesis it has a dual function i.e. dependent on its molecular mass it can promote or inhibit angiogenesis.

Keywords

Hyaluronic Acid Renal Tumour High Molecular Mass Bovine Aortic Endothelial Cell Tympanic Membrane Perforation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • S. Kumar
    • 1
  • J. Ponting
    • 1
  • P. Rooney
    • 2
  • P. Kumar
    • 3
  • D. Pye
    • 1
  • M. Wang
    • 1
  1. 1.Christie Hospital NHS TrustManchesterUK
  2. 2.University of ManchesterUK
  3. 3.Manchester Metropolitan UniversityUK

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