Cellular and Molecular Biology of Endothelial Cell Differentiation during Embryonic Development

  • Thomas J. Poole
Chapter
Part of the NATO ASI Series book series (NSSA, volume 263)

Abstract

How does the pattern of the rudiments of the major blood vessels establish itself in the developing embryo? To understand the cellular biology of these events we must know how the angioblasts, the precursors of endothelial cells, segregate from the mesoderm, migrate, and cohere to one another to form the cords and tubes which are the earliest embryonic blood vessels. We have been using a monoclonal antibody (QH-1) and microsurgery to determine where angioblasts originate and how they assemble into vessel rudiments (Coffin and Poole, 1988; Poole and Coffin, 1989; 1991). The extent and type of directed angioblast migration define three distinct modes of vessel morphogenesis (Poole and Coffin, 1991; Poole, 1993). Vessel rudiments may organize in place, a process termed vasculogenesis, either from angioblasts originating at the rudiment’s location (vasculogenesis type I) or from angioblasts which migrate as individual cells or small groups to that site from different locations (vasculogenesis type II). The dorsal aortae form by the first type of vasculogenesis (Coffin and Poole, 1988; DeRuiter et al., 1993; Pardanaud et al., 1987; Poole and Coffin, 1988; 1989; 1991). The endocardium, ventral aortae and posterior cardinal veins form by the second type (Coffin and Poole, 1991; DeRuiter et al., 1993; Drake and Jacobson, 1988; Poole and Coffin, 1991). New vessels may also form by sprouting from preexisting vessels, a process called angiogenesis. The intersomitic and vertebral arteries are the first vessels to form by angiogenesis, sprouting off the rudiments of the dorsal aortae (Coffin and Poole, 1988; Poole and Coffin, 1988; 1989; 1991). Figure 1 illustrates the different roles of endothelial cells in vasculogenesis and angiogenesis.

Keywords

Endothelial Cell Lineage Avian Embryo Somite Stage Endothelial Cell Differentiation Quail Embryo 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Christ, B., Grim, M., Wilting, J., von Kirschhofer, K., and Wachtler, F., 1991, Differentiation of endothelial cells in avian embryos does not depend on gastrulation, Acta Histochem. 91: 193–199.PubMedCrossRefGoogle Scholar
  2. Coffin, J.D., Harrison, J., Schwartz, S., and Heimark, R., 1991, Angioblast differentiation and morphogenesis of the vascular endothelium in the mouse embryo, Develop. Biol. 148: 51–62.PubMedCrossRefGoogle Scholar
  3. Coffin, J.D. and Poole, T.J., 1988, Embryonic vascular development: Immunohistochemical identification of the origin and subsequent morphogenesis of the major vessel primordia, Development 102: 735–748.PubMedGoogle Scholar
  4. Coffm, J.D. and Poole, T.J., 1991, Endothelial cell origin and migration in embryonic heart and cranial blood vessel development, Anat. Rec. 231: 383–395.CrossRefGoogle Scholar
  5. DeRuiter, M.C., Poelmann, R.E., Mentink, M.M.T., Vaniperen, L., and Gittenberger-De Groot, A.C., 1993, Early formation of the vascular system in quail embryos, Anat. Rec. 235: 261–274.PubMedCrossRefGoogle Scholar
  6. Drake, C.J. and Jacobson, A.G., 1988, A survey by scanning electron microscopy of the extracellular matrix and endothelial components of the primordial chick heart, Anat. Rec. 222: 391–400.PubMedCrossRefGoogle Scholar
  7. Dumont, D.J., Yamaguchi, T.P., Conlon, R.A., Rossant, J., and Breitman, M.L., 1992, TEK, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors, Oncogene 7: 1471–1480.PubMedGoogle Scholar
  8. Dumont, D.J., Gradwohl, G.J., Fong, G.-H., Auerbach, R., and Breitman, M.L., 1993, The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors, Oncogene 8: 1293–1301.PubMedGoogle Scholar
  9. Evans, H.M., 1912, The development of the vascular system, In “Manual of Human Embryology, Vol. II,” in: E. F. Keibel and F.P. Mall, eds., J.B. Lippincott Company, Philadelphia, pp. 570–709.Google Scholar
  10. Flamme, I. and Risau, W., 1992, Induction of vasculogenesis and hematopoiesis in vitro, Development 116: 435–439.PubMedGoogle Scholar
  11. Kokan-Moore, N.P., Bolender, D.L., and Lough, J., 1991, Secretion of inhibin beta by endoderm cultured from early embryonic chicken, Dev. Biol. 146: 242–245.PubMedCrossRefGoogle Scholar
  12. McClure, C.F.W., 1921, The endothelial problem, Anat. Rec. 22: 219–237.CrossRefGoogle Scholar
  13. Millauer, B., Wizigmann-Voos, S., Schnurch, H., Martinez, R., Moller, N.P.H., Risau, W., and Ullrich, A., 1993, High affinity VEGF binding and developmental expression suggest flk-1 as a major regulator of vasculogenesis and angiogenesis, Cell 72: 835–846.PubMedCrossRefGoogle Scholar
  14. Mitrani, E., Gruenbaum, Y., Shohat, H., and Ziv, T., 1990a, Fibroblast growth factor during mesoderm induction in the early chick embryo, Development 109: 387–393.PubMedGoogle Scholar
  15. Mitrani, E., Ziv, T., Thomsen, G., Shimoni, Y., Melton, D.A., and Bril, A., 1990b, Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick, Cell 63: 495–501.PubMedCrossRefGoogle Scholar
  16. Noden, D.M., 1988, Interactions and fates of avian cranio-facial mesenchyme, Development 103 suppl.: 121–140.Google Scholar
  17. Noden, D.M., 1989, Embryonic origins and assembly of blood vessel, Am. Rev. Respir. Dis. 140: 1097–1103.PubMedCrossRefGoogle Scholar
  18. Pardanaud, L., Altmann, C., Kitos, P., Dieterlen-Lievre, F., and Buck, C.A., 1987, Vasculogenesis in the early quail blastodisc as studied with a monoclonal antibody recognizing endothelial cells, Development 100: 339–349.PubMedGoogle Scholar
  19. Pardanaud, L., Yassine, F., and Dieterlen-Lievre, F., 1989, Relationship between vasculogenesis, angiogenesis and hematopoiesis during avian ontongeny, Development 105: 473–485.PubMedGoogle Scholar
  20. Pardanaud, L. and Dieterlen-Lievre, F., 1993, Emergence of endothelial and hemopoietic cells in the avian embryo, Anat. Embryo!. 187: 107–114.Google Scholar
  21. Poole, T.J., 1991, Fibroblast growth factor influences the differentiation and migration of endothelial cells in avian embryos, J. Cell Biol. 115: 366a.Google Scholar
  22. Poole, T.J., 1993, Cell migration in embryonic blood vessel assembly, in Homing Mechanisms and Cellular Targeting. (B.R. Zetter, ed.); pubi. Marcel Decker Inc., New York, New York.Google Scholar
  23. Poole, T.J. and Coffin, J.D., 1988, Developmental angiogenesis: Quail embryonic vasculature, Scanning Microsc. 2: 443–448.PubMedGoogle Scholar
  24. Poole, T.J. and Coffin JD. 1989. Vasculogenesis and angiogenesis: Two distinct morphogenetic mechanisms establish embryonic vascular pattern, J. Exp. Zool. 251: 224–231.PubMedCrossRefGoogle Scholar
  25. Poole, T.J. and Coffin, J.D., 1991, Morphogenetic mechanisms in avian vascular development, in: The Development of the Vascular System. Issues Biomed. (R.N. Feinberg, G.K. Sherer, R. Auerbach, eds.); pubi. S. Karger AG, Basel, Switzerland. vol. 14, pp 25–36.Google Scholar
  26. Sabin, F.R.,1917, Origin and development of the primitive vessels of the chick and of the pig, Contrib. Embryol. Carnegie Inst. Wash. 6: 61–124.Google Scholar
  27. Sabin, F.R., 1920, Studies on the origin of blood vessels and of red blood corpuscles as seen in the living blastoderm of chicks during the second day of incubation, Contrib. Embryol. Carnegie Inst. Wash. 36: 213–259.Google Scholar
  28. Schnurch, H.G. and Risau W., 1991, Differentiating and mature neurons express the acidic fibroblast growth factor gene during chick neural development, Development 111: 1143–1154.PubMedGoogle Scholar
  29. Shiurba, R.A., Jing, N., Sakakura, T., and Godsave, S.F., 1991, Nuclear translocation of fibroblast growth factor during Xenopus mesoderm induction, Development 113: 487–493.Google Scholar
  30. Slack, J.M.W., 1993, Embryonic induction, Mechanisms of Development 41: 91–107.PubMedCrossRefGoogle Scholar
  31. Wang, Z. and Brown, D.D., 1991, A gene expression screen, Proc. Natl. Acad. Sci. USA: 11505–11509.Google Scholar
  32. Yamaguchi, T.P., Dumont, D.J., Conlon, R.A., Breitman, M.L., and Rossant, J., 1993, Fk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors, Development 118: 489–498.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Thomas J. Poole
    • 1
  1. 1.Department of Anatomy & Cell BiologySUNY Health Science Center at SyracuseSyracuseUSA

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