Reactivation of Metalloproteinase-Inhibitor Complex by a Low Molecular Mass Angiogenic Factor
It has now become widely accepted that there is involvement of neutral matrix metalloproteinases (MMPs), in angiogenesis. The initial event in angiogenesis was described by Ausprunk in 1979 as dissolution or degradation of the capillary basement membrane, which it was suggested would permit migration of microvessel endothelial cells through the dense collagenous stroma, enabling penetration of new microvessels. The control of matrix degradation via metalloproteinase activity must therefore be regarded as an important step in the promotion of angiogenesis.
KeywordsHigh Performance Liquid Chromatography Diethyl Amino Ethyl Collagen Type Versus Microvessel Endothelial Cell Capillary Basement Membrane
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