Angiogenesis pp 407-414 | Cite as

Tumor Vascularity, Hypoxia, and Malignant Progression in Solid Neoplasms

  • Michael Höckel
  • Karlheinz Schlenger
  • Billur Aral
  • Uwe Schäffer
  • Wolfgang Weikel
Chapter
Part of the NATO ASI Series book series (NSSA, volume 298)

Abstract

Malignant progression designates the biologic process which transforms a phenotypically normal cell fixed and cooperating within a tissue into a disseminated therapy-resistant lethal disease. In clinical terms this process consists of three major steps (Fig. 1):
  • () the transition from regulated to deregulated cell proliferation,

  • () the emerging ability of the neoplastic cell collectives to induce angiogenesis and to invade other tissues,

  • () the development of metastases and of resistance towards anti-tumor therapies.

Keywords

Cervical Cancer Uterine Cervix Tumor Hypoxia Malignant Progression Tumor Oxygenation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Burghardt, E., Pickel, H., Haas, J., and Lahousen, M., 1987, Prognostic factors and operative treatment of stages IB to IIB cervical cancer, Am. J. Obstet. Gynecol. 156:988–996.PubMedGoogle Scholar
  2. 2.
    Cattoretti, G., Becker, M.H.G., Key, G., Duchrow, M., Schlüter, C., Galle, J., and Gerdes, J., 1992, Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections, J. Pathol. 168:357–363.PubMedCrossRefGoogle Scholar
  3. 3.
    Giaccia, A.J., 1996, Hypoxic stress proteins: survival of the fittest, Semin. Radiat. Oncol. 6:46–58.PubMedCrossRefGoogle Scholar
  4. 4.
    Graeber, T.G., Osmaninan, C., Jacks, T., Housman, D.E., Koch, C.K. Lowe, S.W., and Giaccia, A.J., 1996, Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors, Nature 379:88–91.PubMedCrossRefGoogle Scholar
  5. 5.
    Heacock, C.S., and Sutherland, R.M., 1986, Induction characteristics of oxygen regulated proteins. Int. J. Radial Oncol Biol. Phys. 12:1287–1290.CrossRefGoogle Scholar
  6. 6.
    Höckel, M., Schienger, K., Knoop, C., and Vaupel, P., 1991, Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements, Cancer Res. 51:6098–6102.PubMedGoogle Scholar
  7. 7.
    Höckel, M., Knoop, C., Schlenger, K., Vorndran B., Baussmann, E., Mitze, M., Knapstein, P.G., and Vaupel, P., 1993a, Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix, Radiother. Oncol. 26:45–50.PubMedCrossRefGoogle Scholar
  8. 8.
    Höckel, M., Vorndran, B., Schlenger, K., Baussmann, E., Knapstein, P.G., and Vaupel, P., 1993b, Tumor oxygenation: a new predictive parameter in locally advanced cancer of the uterine cervix, Gynecol. Oncol. 51:141–149.PubMedCrossRefGoogle Scholar
  9. 9.
    Höckel, M., Schlenger, K., Aral, B., Mitze, M., Schäffer, U., and Vaupel, P., 1996, Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix, Cancer Res 56:4509–4515.PubMedGoogle Scholar
  10. 10.
    Kayar, S.R., Archer, P.G., Andrew, A., Lechner, J., and Banchero, N., 1982, The closest-individual method in the analysis of the distribution of capillaries, Microvasc. Res. 24:326–341.PubMedCrossRefGoogle Scholar
  11. 11.
    Rice, G.C., Hoy, C., and Schimke, R.T., 1986, Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells, Proc. Natl. Acad. Sci. USA 83:5978–5982.PubMedCrossRefGoogle Scholar
  12. 12.
    Russo, C.A., Weber, T.K., Volpe, C.M., Stoler, D.L., Petrelli N.J., Rodriguez-Bigas, M., Burhans, W.C., and Anderson G.R., 1995, An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer, Cancer Res. 55:1122–1128.PubMedGoogle Scholar
  13. 13.
    Schmidt-Mathiesen, H., 1988, Histopathologische Basisinformationen als Voraussetzung für individuelle gynäkologische Therapie, Pathologe 9:251 – 257.Google Scholar
  14. 14.
    Sutherland, R.M., Ausserer W., Murphy, B., and Laderoute K., 1996, Tumor hypoxia and heterogeneity: Challenges and opportunities for the future, Semin. Radiat. Oncol. 6:59–70.PubMedCrossRefGoogle Scholar
  15. 15.
    Takahashi, Y., Kitadai, Y., Bucana C.D., Cleary, K.R., and Ellis L.M., 1995, Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer, Cancer Res. 55:3964–3968.PubMedGoogle Scholar
  16. 16.
    Vaupel, P., Kallinowski, F., and Okunieff, P., 1989, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review, Cancer Res. 49:6449–6465.PubMedGoogle Scholar
  17. 17.
    Young, S.D., Marshall, R.S., and Hill R.P., 1988, Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells, Proc. Natl. Acad. Sci. USA 85:9533–9537.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Michael Höckel
    • 1
  • Karlheinz Schlenger
    • 1
  • Billur Aral
    • 1
  • Uwe Schäffer
    • 1
  • Wolfgang Weikel
    • 1
  1. 1.Dept of Ob/GynUniversity of MainzMainzGermany

Personalised recommendations