Angiogenesis pp 377-386 | Cite as

A Peptied From the NC1 Domain of the α3 Chain of Type IV Collagen Prevents Damage to Basement Membranes by PMN

  • Zahra Ziaie
  • Jean-Claude Monboisse
  • Abdelilah Fawzi
  • Georges Bellon
  • Jacques P. Borel
  • Nicholas A. Kefalides
Chapter
Part of the NATO ASI Series book series (NSSA, volume 298)

Abstract

During the process of acute inflammation, circulating polymorphonuclear leukocytes (PMN) transmigrate from the vascular lumen to the site of infection or injury. This process involves the interaction of PMN with endothelial cells (EC) and subsequent diapedesis of PMN through the subendothelial basement membrane (BM). Along the path of transmigration, PMN come across and interact with numerous macromolecules of BM. Extensive research has been carried out to understand how various components of the C M e.g. type IV Collagen (COL (IV)), laminin, entactin, and proteoglycans mediate the physiological function of PMN (Matzner, Bar-Ner, Yahalom, Ishai-Michaeli, Fuks, and Vlodavsky, 1985; Matzer, Vlodavsky, Michaeli, and Eldor, 1990; Pike, Wicha, Yoon, Mayo, and Boxer, 1989; Senior, Hinek, Griffin, Pipoly, Crouch, and Mecham, 1989; Senior, Gresham, Griffin, Brown, and Chung, 1992). Studies by Huber and Weiss (1989) suggest that the transmigrating PMN cause a transient focal disruption of the BM which allows PMN to traverse it. These disruptions are rapidly repaired by the overlying EC. In our laboratory, the focus has been on the role of COL (IV), a major component of the BMs, on PMN function.

Keywords

CD47 Antigen Alport Syndrome Endothelial Cell Monolayer Collagen Chain Endothelial Cell Growth Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barany, G., Merrifield, R. B., 1980, Solid-phase peptide synthesis, in: The peptides, (E. Gross, and J. Meinhofer, eds.) p. 1, Academic Press, Inc., New York.Google Scholar
  2. Cooper, D., Lindberg, F. P., Gamble, J. R., Brown, E. J., and Vadas, M. A., 1995, Transendothelial migration of neutrophils involves integrin-associated protein (CD47), Proc. Natl. Acad. SCi. U.S.A. 92:3978–3982.PubMedCrossRefGoogle Scholar
  3. Gimbrone, M. A., Jr., Cotran, R. S., and Folkman, J., 1974, Human vascular endothelial cells: Growth and DNA synthesis, J. Cell Biol. 60: 673–684PubMedCrossRefGoogle Scholar
  4. Huber, R., and Weiss S. J., 1989, Disruption of the sunendothelial basement membrane during neutrophil diapedesis in an in vitro construct of a blood vessel wall, J. Clin. Invest., 83:1122–1136.PubMedCrossRefGoogle Scholar
  5. Hudson, B. G., Reeders, S. T., and Tryggvason, K., 1993, Type IV collagen: Structure, gene organization, and role in human diseases, J. Biol. Chem. 268:26033–26036.PubMedGoogle Scholar
  6. Kamagata, Y., Mattei, M.-G., and Ninomiya, Y., 1992, Isolation and sequencing of cDNAs and genomic DNAs encoding the α4 chain of basement membrane collagen type IV and assignment of the gene to the distal long arm of human chromosome 2, J. Biol. Chem. 267:23753–23758.PubMedGoogle Scholar
  7. Kefalides, N.A., Ohno, N., Wilson, CM., Fillet, M, Zabriski, J. and Rosenbloom, J., 1993. Identification of antigenic epitopes in type IV collagen by use of synthetic peptides, Kidney Int., 43:94–100.PubMedCrossRefGoogle Scholar
  8. Mariyama, M., Leinonen, A., Mochizuki, T., Tryggvason, K., and Reeders, S. T., 1994, Complete primary structure of the human α3(IV) collagen chain. Co-expression of the α3(IV) and α4(IV) collagen chains in human tissues, J. Biol. Chem. 269:23013–23017.PubMedGoogle Scholar
  9. Matzner, Y., Bar-Ner, M., Yahalom, J., Ishai-Michaeli, R., Fuks, Z, and Vlodavsky, L, 1985, Degradation of haparan sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophils, J. Clin. Invest, 76:1306–1313.PubMedCrossRefGoogle Scholar
  10. Matzner, Y., Vlodavsky, I, Michaeli, R, and Eldor, A., 1990, Selective inhibition of neutrophil activation by the subendothelial extracellular matrix: Possible role in protection of the vessel wall during diapedesis, Exp. Cell Res. 189:233–240.PubMedCrossRefGoogle Scholar
  11. Monboisse, J. C., Bellon, G., Randoux, A., Dufer, J., and Borel, J. P., 1990, Activation of human neutrophils by type I collagen, Biochem. J. 270:459–462.PubMedGoogle Scholar
  12. Monboisse, J. C., Bellon, G., Perreau, C., Garnotel, R., and Borel, J. P., 1991, Bovine lens capsule basement membrane collagen exerts a negative priming on polymorphonuclear neutrophils, FEBS Lett. 294:129–132.PubMedCrossRefGoogle Scholar
  13. Monboisse, J. C, Garnotel, R., Bellon, G., Ohno, N., Perreau, C, Borel, J. P., and Kefalides, N. A., 1994, The a3 chain of type IV collagen prevents activation of human polymorphonuclear leukocytes, J. Biol Chem. 269:25475–25482.PubMedGoogle Scholar
  14. Ninomiya, Y., Kagawa, M., Iyama, K., Naito, I., Kishiro, Y., Seyer, J. M., Sugimoto, M., Ooahashi, T., and Sado, Y., 1995, Differential expression of two basement membrane collagen genes, COL4A6 and COL4A5, demonstrated by immunofluorescence staining using peptide-specific monoclonal antibodies, J. Cell Biol. 130:1219–1229.PubMedCrossRefGoogle Scholar
  15. Pike, M. C, Wicha, M. S., Yoon, P., Mayo, L., and Boxer, L. A., 1989, Laminin promotes the oxidative burst in human neutrophils via increased chemoattractant receptor expression, J.Immunol. 142:2004–2011.PubMedGoogle Scholar
  16. Senior, R. M., Hinek, A., Griffin, G. L., Pipoly, D. J., Crouch, E. C, and Mecham, R. P., 1989, Neutrophils show Chemotaxis to type IV collagen and its 7S domain and contain a 67 kD type IV collagen binding protein with lectin properties, Am. J. Respir. Cell Mol. Biol. 1:479.487.Google Scholar
  17. Senior, R. M., Gresham, H. D., Griffin, G. L., Brown, E. J., and Chung, A. E., 1992, Entactin stimulates neutrophil adhesion and Chemotaxis through interactions between its Arg-Gly-Asp (RGD) domain and the leukocyte response integrin, J. Clin. Invest. 90:2251–2257.PubMedCrossRefGoogle Scholar
  18. Zhou, J., Hertz, J. M., Leinonen, A., and Tryggvason, K., 1992, Complete amino acid sequence of the human a5(IV) collagen chain and identification of a single-base mutation in exon 23 converting glycine521 in the collagenous domain to cysteine in an Alport syndrome patient, J. Biol. Chem. 267:12475–12481.PubMedGoogle Scholar
  19. Zhou, J., Ding, M., and Reeders, S., 1994, Complete primary structure of the sixth chain of human basement membrane collagen, a6(IV), J. Biol Chem. 269:13193–13199.PubMedGoogle Scholar
  20. Ziaie, Z, Friedman, H. M., Kefalides, N. A., 1986, Suppression of matrix protein synthesis by herpes simplex virus type 1 in human endothelial cells, Collagen Rel Res. 6:333–350.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Zahra Ziaie
    • 1
  • Jean-Claude Monboisse
    • 2
  • Abdelilah Fawzi
    • 2
  • Georges Bellon
    • 2
  • Jacques P. Borel
    • 2
  • Nicholas A. Kefalides
    • 1
  1. 1.Connective Tissue Research Institute and Department of MedicineUniversity of Pennsylvania and University City Science CenterPhiladelphiaUSA
  2. 2.Laboratory of Biochemistry, CNRS UPRESA, 6021University of ReimsReimsFrance

Personalised recommendations