Angiogenesis pp 263-282 | Cite as

Cellular and Molecular Effects of Thrombin in the Vascular System

  • Chryso Kanthou
  • Vijay Vir Kakkar
  • Omar Benzakour
Chapter
Part of the NATO ASI Series book series (NSSA, volume 298)

Abstract

Two distinct physiological processes lead to the development of new blood vessels: vasculogenesis and angiogenesis [reviewed by Risau, 1997]. Whereas vasculogenesis is restricted to embryonic development and consists in the differentiation of mesodermal precursor cells into endothelial cells followed by their organisation into the capillary plexus, angiogenesis is the formation of new capillaries from pre-existing blood vessels and takes place both during prenatal and adult life. Angiogenesis can occur under both physiological and pathological conditions such as during wound healing and solid tumour development. Moreover, intra-arterial angiogenesis is evident in atherosclerotic plaques and in recanalised thrombi [reviewed by Eisenstein, 1991]. The cellular and molecular events that lead to angiogenesis are not as yet fully elucidated but are known to include (i) breakdown of the extracellular matrix and of basement membrane of pre-existing blood vessels; (ii) the migration and proliferation of endothelial cells; (iii) production of extracellular matrix allowing the reconstitution of the basement membrane; (iv) recruitment of pericytes and vascular smooth muscle cells (VSMC) to the newly formed blood vessel.

Keywords

Vascular Smooth Muscle Cell Mitogenic Effect Thrombin Receptor Potent Mitogen Human Vascular Smooth Muscle Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Chryso Kanthou
    • 1
  • Vijay Vir Kakkar
    • 1
  • Omar Benzakour
    • 1
  1. 1.Thrombosis Research InstituteEmmanuel Kaye BuildingLondonUK

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