Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in Autoimmune Liver Disease

  • A. H. Leontine Mulder
  • Gerda Horst
  • Els B. Haagsma
  • Jan H. Kleibeuker
  • Cees G. M. Kallenberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

ANCA were detected in 67% of sera from patients with primary sclerosing cholangitis (n=15), in 83% of sera from patients with auto-immune chronic active hepatitis (n=18) and in 35% of sera from patients with primary biliary cirrhosis (n=20). ANCA were not detected in non-autoimmune chronic liver diseases. Characterization studies of the antigens involved showed that ANCA in autimmune liver disease are not directed against myeloperoxidase (mpo), proteinase 3 (pr3) or elastase (hle), but that ANCA in autoimmune liver disease show reactivity with lactoferrin, a 67/66 kD protein combination or a 63/54 kD protein combination on Western Blots.

Keywords

Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Antineutrophil Cytoplasmic Antibody Primary Biliary Cirrhosis Patient Crescentic Glomerulonephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • A. H. Leontine Mulder
    • 1
  • Gerda Horst
    • 1
  • Els B. Haagsma
    • 2
  • Jan H. Kleibeuker
    • 2
  • Cees G. M. Kallenberg
    • 1
  1. 1.Department of Clinical ImmunologyUniversity Hospital GroningenGroningenThe Netherlands
  2. 2.Department of GastroenterologyUniversity Hospital GroningenGroningenThe Netherlands

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