Detection of Antineutrophil Cytoplasmatic Antibodies (ANCA) and their Association with other Autoantibodies in Patients with Hepatobiliary Disorders
Sera from 35 out of 655 patients with suspected or confirmed hepatobiliary diseases were positive for anti-neutrophil antibodies with a perinuclear staining pattern (p-ANCA). Nineteen of these sera did not react with myeloperoxidase (MPO), Cathepsin G or Elastase, the three proposed antigens of p-ANCAs. No distinct antigen for these sera could be characterized by western blot techniques with fractionated granulocyte proteins.
KeywordsPrimary Biliary Cirrhosis Primary Sclerosing Cholangitis Chronic Active Hepatitis Hepatobiliary Disease Western Blot Technique
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