Anti-Granulocyte Perinuclear Antibodies but Not Anti-Neutrophil Cytoplasmic Antibodies (ANCA) in Rheumatoid Arthritis

  • X. Bosch
  • J. Llena
  • J. Font
  • A. Collado
  • E. Mirapeix
  • A. Urbano-Marquez
  • M. Ingelmo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

We studied 45 patients with rheumatoid arthritis for the presence of ANCA. These antibodies were determined by indirect immunofluorescence (IIF) and by enzyme-linked immunosorbent assays (ELISAs) using as a substrate purified myeloperoxidase and purified extract of azurophilic granules. By IIF, we found a characteristic perinuclear immunostaining pattern in 21 cases (47%). However, no patient had a positive result by the two ELISAs performed. Patients with a positive IIF result had significantly higher levels of anti-nuclear and anti-ds DNA antibodies than those with a negative IIF result. Therefore, these antibodies must correspond to the previously reported as granulocyte specific antinuclear antibodies (GS-ANA).

Keywords

Rheumatoid Arthritis Rheumatoid Arthritis Patient Antineutrophil Cytoplasmic Antibody Crescentic Glomerulonephritis Immunostaining Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • X. Bosch
    • 1
  • J. Llena
    • 2
  • J. Font
    • 1
  • A. Collado
    • 2
  • E. Mirapeix
    • 3
  • A. Urbano-Marquez
    • 1
  • M. Ingelmo
    • 1
  1. 1.Service of Internal MedicineBarcelonaSpain
  2. 2.Service of RheumatologyBarcelonaSpain
  3. 3.Service of Nephrology Hospital Clinic i ProvincialBarcelonaSpain

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