The Clinical, Serologic, and Immunopathologic Heterogeneity of Cutaneous Leukocytoclastic Angiitis

  • J. Charles Jennette
  • Robin Tuttle
  • Ronald J. Falk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Abstract

Histologically identical cutaneous leukocytoclastic angiitis occurs in patients with different serologic markers for vasculitis. When categorized on the basis of serologic analysis for antineutrophil cytoplasmic autoantibodies and IgA fibronectin aggregates, categories of leukocytoclastic angiitis have many overlapping features; however, there are distinctive clinical and immunopathologic trends among the categories. When both serologic tests are negative, there is a low probability that systemic vasculitis is present. The presence of either serologic marker indicates a strong probability for the presence of extracutaneous vasculitis and/or glomerulonephritis.

Keywords

Systemic Vasculitis Serologic Marker Polyarteritis Nodosa Serologic Analysis Immune Complex Deposit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Jennette J.C., Falk R.J., 1990, Anti-neutrophil cytoplasmic autoantibodies and associated diseases: A review. Am JKidney Dis 15:517 Google Scholar
  2. Jennette J.C., Wieslander J., Tuttle R., Falk R.J., Glomerular Disease Collaborative Network, 1991, Serum IgA-fibronectin aggregates in patients with IgA nephropathy and Henoch-Schönlein purpura: Diagnostic value and pathogenic implications. Am JKidney Dis 18:466 Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • J. Charles Jennette
    • 1
  • Robin Tuttle
    • 1
  • Ronald J. Falk
    • 2
  1. 1.Departments of PathologyUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.Departments of MedicineUniversity of North Carolina School of MedicineChapel HillUSA

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