Relationship Between Disease Activity and ANCA Level by Elisa in the Long-Term Management of Vasculitis

  • J. De’Oliviera
  • G. Gaskin
  • A. Dash
  • A. J. Rees
  • C. D. Pusey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Solid-phase immunoassays were used to examine the relationship between ANCA concentration and disease activity during follow-up of 63 patients with systemic vasculitis. ANCA levels fell with induction therapy. Relapses during long-term follow-up were generally associated with high or rising ANCA concentrations, although the temporal relationship between clinical relapse and changes in ANCA was variable.

Keywords

Induction Therapy Systemic Vasculitis Clinical Relapse Royal Postgraduate Medical School ANCA Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Cohen Tervaert, J. W., van der Woude, F. J., Fauci, A. S., Ambrus, J. L., Velosa, J., Keane, W. F., Meijer, S., van der Giessen, M., The, T. H., van der Hem, G. K., and Kallenberg, C. G. M. 1989. Association between active Wegener’s granulomatosis and anticytoplasmic antibodies. Arch. Intern. Med. 149: 2461–2465.CrossRefGoogle Scholar
  2. Gaskin, G., Savage, C. O. S., Ryan, J. J., Jones, S., Rees, A. J., Lockwood, C. M., and Pusey, C. D. 1991. Anti-neutrophil cytoplasmic antibodies and disease activity during long-term follow-up of 70 patients with systemic vasculitis. Nephrol Dial Transplant 6: 689–694.PubMedCrossRefGoogle Scholar
  3. Lee, S.S., Adu,D., and Thompson, R.A. 1990. Anti-myeloperoxidase antibodies in systemic vasculitis. Clin Exp Immunol 79. 41–46.Google Scholar
  4. Nölle, B., Specks,U,. Lüdemann, J, Rohrbach, M.S., DeRemee, R.A., and Gross, W.L. 1989. Anticytoplasmic antibodies and their immunodiagnostic value in Wegener’s granulomatosis. Ann Int Med 111: 28–40.Google Scholar
  5. Rasmussen, N., Sjolin, C., Isakkson, B., Bygren, P., and Wieslander, J. 1990. An ELISA for the detection of anti-neutrophil cytoplasmic antibodies (ANCA). Jlmmunol Methods 127: 139–145.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • J. De’Oliviera
    • 1
  • G. Gaskin
    • 1
  • A. Dash
    • 1
  • A. J. Rees
    • 1
  • C. D. Pusey
    • 1
  1. 1.Renal Unit Department of MedicineRoyal Postgraduate Medical SchoolLondonUK

Personalised recommendations