Significance of Autoantibodies to Purified Proteinase 3 in Systemic Vasculitis

  • G. Gaskin
  • A. N. Turner
  • J. J. Ryan
  • A. J. Rees
  • C. D. Pusey
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Proteinase 3 was purified from human neutrophils and used in ELISA to examine sera from 150 patients with systemic vasculitis. It was found to be the major target of autoantibodies in Wegener’s granulomatosis, and anti-proteinase 3 antibodies were also found in some patients with microscopic polyarteritis. Anti-proteinase 3 antibodies were associated with a chronic relapsing course.

Keywords

Human Neutrophil Systemic Vasculitis Primary Granule Primary Systemic Vasculitis Royal Postgraduate Medical School 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • G. Gaskin
    • 1
  • A. N. Turner
    • 1
  • J. J. Ryan
    • 1
  • A. J. Rees
    • 1
  • C. D. Pusey
    • 1
  1. 1.Renal Unit Department of MedicineRoyal Postgraduate Medical SchoolLondonUK

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