Anti-Neutrophil Cytoplasmic Autoantibodies (ANCA): Antigenic Specificities and Clinical Associations

  • X. Bosch
  • J. Font
  • E. Mirapeix
  • L. Revert
  • A. Urbano-Márquez
  • M. Ingelmo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

We have conducted a prospective study of 372 patients with well-defined forms of systemic vasculitis and connective tissue diseases to determine the prevalence, the antigenic specificities and the clinical associations of ANCA in such cases. These antibodies were detected by indirect immunofluorescence on ethanol-fixed neutrophils and also by enzyme-linked immunosorbent assay using myeloperoxidase (MPO) as a substrate. In our study, ANCA with a cytoplasmic immunostaining pattern were mainly found in patients with biopsy-proven Wegener’s granulomatosis with or without renal involvement and pulmonary hemorrhage. Furthermore, MPO-ANCA strongly correlated with necrotizing glomerular and alveolar capillaritis, mostly in patients having a well-established diagnosis of polyarteritis nodosa.

Keywords

Renal Involvement Systemic Vasculitis Takayasu Arteritis Polyarteritis Nodosa Progressive Systemic Sclerosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • X. Bosch
    • 1
  • J. Font
    • 1
  • E. Mirapeix
    • 2
  • L. Revert
    • 2
  • A. Urbano-Márquez
    • 1
  • M. Ingelmo
    • 1
  1. 1.Service of Internal MedicineHospital Clínic i ProvincialBarcelonaSpain
  2. 2.Service of NephrologyHospital Clínic i ProvincialBarcelonaSpain

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