ANCA in Systemic Vasculitides, Collagen Vascular Diseases, Rheumatic Disorders and Inflammatory Bowel Diseases

  • Stefanie Hauschild
  • Wilhelm H. Schmitt
  • Elena Csernok
  • Brigitte K. Flesch
  • Annegret Rautmann
  • Wolfgang L. Gross
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Abstract

It was the aim of this study to reevaluate the diagnostic significance and clinical implication of ANCA after testing sera from 13606 patients for the presence of ANCA. Our data confirm the high specificity (97%) and sensitivity (80%) of cANCA for Wegener’s granulomatosis. pANCA were found in renal vasculitides (60%), collagen vascular diseases (SLE 20%, Sjögren’s syndrome 26%, polymyositis 16%) and rheumatic disorders (Felty’s syndrome 50%, rheumatoid arthritis 20%). A third fluorescence pattern in sera of patients with inflammatory bowel disease (ulcerative colitis 28/72, Crohn’s disease 6/ 84), here called xANCA, was seen. Target antigens of granule proteins from PMN and monocytes (proteinase 3, myeloperoxidase, elastase, cathepsin G, lactoferrin, lysozyme) were identified.

Keywords

Inflammatory Bowel Disease Ulcerative Colitis Giant Cell Arteritis Antineutrophil Cytoplasmic Antibody Rheumatic Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Stefanie Hauschild
    • 1
  • Wilhelm H. Schmitt
    • 1
  • Elena Csernok
    • 1
  • Brigitte K. Flesch
    • 1
  • Annegret Rautmann
    • 1
  • Wolfgang L. Gross
    • 1
  1. 1.Dept. of Rheumatology, Medical University of Lübeck and Medical DepartmentRheumaklinik Bad Bramstedt GmbHGermany

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