Myeloperoxidase Binds to Vascular Endothelial Cells, is Recognized by ANCA and can Enhance Complement Dependent Cytotoxicity
Myeloperoxidase (MPO) and proteinase-3 (Pr-3) can bind to vascular endothelial cells (EC) and are available for recognition by autoantibodies present in P-ANCA or C-ANCA containing sera, respectively. The bound MPO also retains its enzymic functions and effectively interacts with hydrogen peroxide to mediate detachment of endothelial cells from their substratum. EC bound MPO-anti-MPO complexes can contribute to the complement-dependent EC injury demonstrated by some P-ANCA sera.
KeywordsHypochlorous Acid Complement Dependent Cytotoxicity Alkaline Phosphatase Detection Microscopic Polyarteritis Control Endothelial Cell
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