Effect of Ciliary Neurotrophic Factor on β-Amyloid Precursor Protein mRNA Expression

  • Shinji Sudoh
  • Hideshi Kawakami
  • Yasuyo Mimori
  • Mituhiro Ohta
  • Shigenobu Nakamura
Part of the Advances in Behavioral Biology book series (ABBI, volume 44)

Abstract

The neuropathological hallmark of Alzheimer’s disease is the progressive accumulation of senile plaques. The major constituent of senile plaques is amyloid β/A4 protein. This β/A4 peptide consists of 42–43 amino acids and is derived from a large transmembrane protein,the β-amyloid precursor protein (APP).5 The APP gene is expressed in various tissues and is highly conserved in evolution. In addition, three major isoforms (APP695, APP751, APP770) are generated from a single gene by alternative splicing, two of which (APP751,APP770) contain the Kunitz-type protease inhibitor (KPI) domain. APP is presumed to play an important role in physiological or pathological conditions. However, the mechanisms regulating APP are yet unknown.

Keywords

Ciliary Neurotrophic Factor Cerebral Cortical Neuron Ciliary Ganglion Neuron Large Transmembrane Protein CNTF Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Shinji Sudoh
    • 1
  • Hideshi Kawakami
    • 1
  • Yasuyo Mimori
    • 1
  • Mituhiro Ohta
    • 2
  • Shigenobu Nakamura
    • 1
  1. 1.Third Department of Internal Medicine School of MedicineHiroshima UniversityHiroshima 734Japan
  2. 2.Clinical Research LaboratoriesUtano National HospitalKyoto 616Japan

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