Chemistry of Collagen Crosslinking: Relationship to Aging and Nutrition

  • Philip E. McClain
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 86)

Abstract

Collagen is a major constituent of skin, bone, tendon, and cartilage and is a vital component of the cardiovascular system. Not only is collagen an important protein because of its relative abundance, estimates indicate that it constitutes as much as 40% of the total body protein, but also it is the only protein in the body that has been clearly shown to undergo molecular changes during the aging process in man and animals, i. e., it “ages.” One of the outward manifestations of aging in collagen is the wrinkling of the skin which is inevitable in the elderly. Another, which is not so obvious but is of infinitely greater importance to man is the age-associated loss of elasticity in the cardiovascular system.

Keywords

Copper Deficiency Collagen Crosslinking Lysyl Oxidase Skin Collagen Thermal Shrinkage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Philip E. McClain
    • 1
  1. 1.U. S. Department of AgricultureAgricultural Research Service, Nutrition InstituteBeltsvilleUSA

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