Do Sex-Related Differences Exist in the Respiratory Pharmacology of Opioids?

  • Elise Sarton
  • Albert Dahan
  • Luc Teppema
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 450)

Abstract

There are strong indications from human and animal studies (especially from studies using inbred strains of mice), that strain and sex-related differences exist in the analgesic potency of endogenous and exogenous administered opioids, as well as in the neurochemical and genetic mechanisms activated to modulate pain. 1–6 These differences are not restricted to the analgesic properties of opioids. Opioid-induced lethality, changes in locomotor activity, opioid addiction and opioid discrimination also exhibit sex- and/or strain-related differences.1, 3,7 Studies on strain- or sex-related differences in the influence of opioids on ventilatory control are scarce. We retrieved one study from the literature. Muraki and Kato studied the influence of morphine on the occurrence of hypothermia and respiratory rate in six strains of male mice. 8 They observed significant strain differences in these two measures of morphine action.

Keywords

Luteal Phasis Ventilatory Response Ventilatory Control Intravenous Morphine Median Preoptic Area 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Mogil, J.S., S.P. Richards, L.A. O’Toole, M.L. Helms, S.R. Mitchell, and J.K. Belknap. Genetic sensitivity to hot-plate nociception in DBA/2J and C57BL/6J inbred mouse strains: possible sex-specific mediation by δ2-opiod receptors. Pain 70: 267–277, 1997PubMedCrossRefGoogle Scholar
  2. 2.
    Mogil J.S., W.F. Sternberg, P. Marek, B. Sadowski, J.K. Belknap, and J.C. Liebeskind. The genetics of pain and pain inhibition. Proc Natl Acad Sci USA 1996; 93: 3048–55, 1996.CrossRefGoogle Scholar
  3. 3.
    Frischknecht H.R., B. Siegfried, and P.G. Waser. Opioids and behavior: genetic aspects. Experientia 44: 473–81, 1988.PubMedCrossRefGoogle Scholar
  4. 4.
    Cicero, H.J., B. Nock, and E.R. Meyer. Gender-related differences in the antinociceptive properties of morphine. J. Pharmacol. Exp. Then 279: 767–773, 1996.Google Scholar
  5. 5.
    Kaveliers, M., and D.G.L. Innes. Stress-induced opioid analgesia and activity in deer mice: sex and population differences. Brain Res. 425: 49–56, 1987.CrossRefGoogle Scholar
  6. 6.
    Gear, R.W., C. Miaskowski, N.C. Gordon, S.M. Paul, P.H. Heller, and J.D. Levine. Kappa-opioids produce significantly greater analgesia in women than in men. Nature Med. 2: 1248–50, 1996.PubMedCrossRefGoogle Scholar
  7. 7.
    Moskowitz, A.S., G.W. Terman, K.R. Carter, M.J. Morgan, and J.C. Liebeskind. Analgesic, locomotor and lethal effects of morphine in the mouse: strain comparisons. Brain Res. 361: 46–51, 1985.PubMedCrossRefGoogle Scholar
  8. 8.
    Muraki, T., and R. Kato. Strain differences in the effects of morphine on the rectal temperature and respiratory rate in male mics. Psychopharm 89: 60–64, 1986.CrossRefGoogle Scholar
  9. 9.
    Dahan, A., E. Sarton, L. Teppema, and C. Olievier. Sex-related differences in the influence of morphine on ventilatory control in humans. Anesthesiology, in press.Google Scholar
  10. 10.
    Bourke, D.L., and A. Warley. The steady-state and rebreathing methods compared during morphine administration in humans. J. Physiol. Lond. 419: 509–517, 1989.PubMedGoogle Scholar
  11. 11.
    White, D.P., B.K. Schneider, R.J. Santen, M. McDermott, C.K. Pickett, C.W. Zwillich, and J.V. Weil. Influence of testosterone on ventilation and chemosensitivity in male subjects. J. Appl. Physiol. 59: 1452–1457, 1985.PubMedGoogle Scholar
  12. 12.
    Arnold, A.P., and S.M. Breedlove. Organizational and activational effects of sex steroids on brain behavior: a reanalysis. Horm. Behav. 19: 469–498, 1985.PubMedCrossRefGoogle Scholar
  13. 13.
    Breedlove, S.M. Sexual differentiation of the human nervous system. Ann. Rev. Psychol. 45: 389–418, 1994.CrossRefGoogle Scholar
  14. 14.
    Hammer, R.P. The sexually dimorphic region of the pre-optic area in rats contains denser opiate receptor binding sites in females. Brain Res. 308: 172–176, 1984.PubMedCrossRefGoogle Scholar
  15. 15.
    McQueen, J.S., and J.A. Ribeiro. Inhibitory actions of methionine-enkephalin and morphine an the cat carotid chemoreceptor. Br. J. Pharmacol. 71: 297–305, 1980.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Elise Sarton
    • 1
  • Albert Dahan
    • 1
  • Luc Teppema
    • 1
  1. 1.Departments of Anesthesiology and PhysiologyLeiden University Medical CenterLeidenThe Netherlands

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