Regulation by Lactoferrin of Epidermal Langerhans Cell Migration
Lactoferrin is an iron-binding glycoprotein that shares structural homology with transferrin and which is found in milk, other epithelial secretions and the secondary granules of neutrophils1. One function ascribed to lactoferrin is that of antibacterial activity which is effected primarily through the sequestration of iron necessary for microbial growth1,2. It is recognized, however, that in addition to its bacteriostatic properties, lactoferrin may serve as a modulator of immune and inflammatory responses. Of particular interest is the observation that this glycoprotein may influence the production of some cytokines, including proinflammatory cytokines 1–3. Among the cytokines shown to be regulated negatively by lactoferrin are tumour necrosis factor a (TNF-α), interleukin 1β (IL-1β) and granulocyte/macrophage colony-stimulating factor (GM-CSF)2–4. It has been demonstrated that (bovine) lactoferrin administered intravenously to mice prior to an injection of bacterial lipopolysaccharide (LPS) inhibited significantly the production of TNF-α normally induced by LPS5. It has been argued, however, that the ability of lactoferrin to inhibit the stimulation of TNF-α by LPS may be secondary to its capacity to bind LPS and thereby compromise the signal for cytokine production3.
KeywordsDrain Lymph Node Intradermal Injection Skin Sensitization Human Lactoferrin Bovine Serum Albu
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