Pharmacokinetics of Linear Reversible Metabolic Systems

  • Haiyung Cheng
  • William J. Jusko

Abstract

The role of reversible metabolism in pharmacology and pharmacokinetics has been gradually appreciated. Many compounds undergo this process. For example, commonly-used drugs such as captopril [1, 2], sulindac [3, 4], methylprednisolone [5, 6], lovastatin [7, 8], procainamide [9–11], imipramine [12, 13], and clofibric acid [14–16] have interconversion metabolites. Additional examples of drugs [17–31] which undergo reversible metabolism are listed in Table I. These compounds can be generally categorized according to their metabolically affected groups as: sulfides, sulfoxides, alcohols, lactones, arylamines, tertiary amines, and carboxylic acids.

Keywords

Parent Drug Tertiary Amine Central Compartment Clofibric Acid Distribution Clearance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • Haiyung Cheng
    • 1
    • 2
  • William J. Jusko
    • 1
  1. 1.Department of PharmaceuticsState University of New York at BuffaloUSA
  2. 2.Merck Sharp & Dohme Research LaboratoriesUSA

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