Immunology pp 265-288 | Cite as

Lymphocyte Mediators That Modulate the Behavior of Macrophages

  • Ross Rocklin

Abstract

T lymphocytes mediate a number of cellular-immune reactions including cutaneous delayed hypersensitivity of the tuberculin or contact types, resistance to infection by intracellular facultative microorganisms, host versus graft and graft versus host rejection phenomena, and tumor surveillance. These reactions result from complex cellular interactions between subpopulations of T lymphocytes and T lymphocytes and macrophages. The T cell may function directly as an effector cell or indirectly by orchestrating interactions between lymphocytes and macrophages. As a result of these activation signals, the macrophage may then develop into a more efficient phagocytic “killer cell” or in turn transmit signals that modulate T-cell functions in either a positive or a negative way.

Keywords

Migration Inhibitory Factor Human Monocyte Complement Receptor Macrophage Migration Inhibitory Factor Tumoricidal Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Altman, L. C., 1978, Monocyte chemotactic factor, in: Leukocyte Chemotaxis (J. I. Gallin and P. G. Quie, eds.), p. 267, Raven Press, New York.Google Scholar
  2. Altman, L. C., Snyderman, R., Oppenheim, J. J., and Mergenhagen, S. E., 1973, A human mononuclear leukocytic chemotactic factor: Characterization, specificity and kinetics of production by homologous leukocytes, J. Immunol. 110:801.PubMedGoogle Scholar
  3. Altman, L. C., Chassy, B., and Macklin, B. F., 1975, Physicochemical characterization of chemotactic lymphokines produced by human T and B lymphocytes, J. Immunol. 115:18.PubMedGoogle Scholar
  4. Anderson, S. E., and Remington, J. S., 1974, Effect of normal and activated human macrophages on Toxoplasma gondii, J. Exp. Med. 139:1154.CrossRefGoogle Scholar
  5. Anderson, S. E., Bautista, S., and Remington, J. S., 1976, Induction of resistance to Toxoplasma gondii in human macrophages by soluble lymphocyte products, J. Immunol. 117:381.PubMedGoogle Scholar
  6. Balow, J. E., and Rosenthal, A. S., 1973, Glucocorticoid suppression of macrophage migration inhibitory factor, J. Exp. Med. 137:1031.PubMedCrossRefGoogle Scholar
  7. Bartfeld, H., and Atoynatan, T., 1971, Activity and properties of macrophage migration inhibitory factor produced in MLC, Nature (London) 230:246.CrossRefGoogle Scholar
  8. Beer, D. J., Dinarello, C. A., Rosenwasser, L. J., and Rocklin, R. E., 1982, Human monocyte-derived soluble product has an accessory function in the generation of histamine- and concanavalin Ainduced suppressor T cells, J. Clin. Invest. 70:393.PubMedCrossRefGoogle Scholar
  9. Block, L. H., Bernheim, H. A., and Jacksche, H., 1980, Purified human MIF: Effects on oxidative metabolism and surface architecture of effector cells, in: Biochemical Characterization of Lymphokines (A. deWeck, ed.), p. 79, Academic Press, New York.Google Scholar
  10. Bloom, B. L., Gaffney, J., and Jimenez, L., 1972, Dissociation of MIF production and cell proliferation, J. Immunol. 109:1395.PubMedGoogle Scholar
  11. Borgis, J. S., and Johnson, W. D., 1974, Inhibition of multiplication of Toxoplasma gondii by human monocytes exposed to T-lymphocyte products, J. Exp. Med. 141:483.CrossRefGoogle Scholar
  12. Bray, M. A., Gordon, D., and Morley, J., 1978, Prostaglandins as regulators in cellular immunity, Prostaglandins Med. 1:183.PubMedCrossRefGoogle Scholar
  13. Chao, P., Francis, L., and Atkins, E., 1977, The release of an endogenous pyrogen from guinea pigs in vitro, J. Exp. Med. 145:1288.PubMedCrossRefGoogle Scholar
  14. Churchill, W. H., and Cameron, D., 1980, Macrophage activating factor (MAF) induced cytotoxicity: Similarities in man and guinea pig, in: Biochemical Characterization of Lymphokines (A. de Weck, ed.), p. 137, Academic Press, New York.Google Scholar
  15. Churchill, W. H., and Wong, C., 1980, Mediator-induced macrophage activation as shown by enhanced cytotoxicity for tumor, requires macrophages surface fucose and sialic acid, Cell. Immunol. 55:490.PubMedCrossRefGoogle Scholar
  16. Churchill, W. H., Piessens, W. F., Sulis, C. A., and David, J. R., 1975, Macrophages activated as suspension cultures with lymphocyte mediators devoid of antigen become cytotoxic for tumor cells, J. Immunol. 115:781.PubMedGoogle Scholar
  17. Cohen, S., and Yoshida, T., 1977, Suppression of B cell MIF production by T cells and soluble T cellderived factors, J. Immunol. 119:719.PubMedGoogle Scholar
  18. Colvin, R. B., Johnson, R. A., Mihm, M. C., and Dvorak, H. F., 1973, Role of the clotting system in cell-mediated hypersensitivity: Fibrin deposition in delayed skin reactions in man, J. Exp. Med. 138:686.PubMedCrossRefGoogle Scholar
  19. David, J. R., 1966, Delayed hypersensitivity in vitro: Its mediation by cell-free substances formed by lymphoid cell—antigen interactions, Proc. Natl. Acad. Sci. USA 56:72.PubMedCrossRefGoogle Scholar
  20. David, J. R., and David, R. A., 1972, Cellular hypersensitivity and immunity: Inhibition of macrophage migration and lymphocyte mediators, Prog. Allergy 16:300.PubMedGoogle Scholar
  21. Dinarello, C. A., and Rosenwasser, L. J., 1981, Lymphocyte activating property of human leukocytic pyrogen, in: Advances in Immunopharmacology (J. W. Hadden, L. Chedid, and P. Mullen, eds.), p. 419, Pergamon Press, Elmsford, N.Y.Google Scholar
  22. Dumonde, D. C., Page, D. A., Matthew, M., and Wolstencroft, R. A., 1972, Role of lymphocyte activation products (LAP) in cell-mediated immunity, Clin. Immunol. Immunopathol. 10:25.Google Scholar
  23. Dvorak, A. M., Hammond, M. E., Dvorak, H. F., and Karnovsky, M. J., 1972, Loss of cell surface material from peritoneal exudate cells associated with MIF activity, Lab. Invest. 27:561.PubMedGoogle Scholar
  24. Edwards, R. L., and Rickles, F. R., 1978, Delayed hypersensitivity: Effect of systemic anticoagulation, Science 200:541.PubMedCrossRefGoogle Scholar
  25. Edwards, R. L., and Rickles, F. R., 1980, The role of human T cells (and T cell products) for monocytic tissue factor generation, J. Immunol. 125:606.PubMedGoogle Scholar
  26. Evans, R., and Alexander, P., 1976, Mechanisms of extra-cellular killing of nucleated mammalian cells by macrophages, in: Immunobiology of the Macrophage (D. S. Nelson, ed.), p. 536, Academic Press, New York.Google Scholar
  27. Fidler, I. J., Darnell, J. H., and Budmen, M. D., 1977, Tumoricidal properties of mouse macrophages activated with mediators from rat lymphocytes stimulated with Con A, J. Immunol. 117:666.Google Scholar
  28. Folger, W. E., Raz, A., and Fidler, I. J., 1980, In situ activation of murine macrophages by liposomes containing lymphokines, Cell. Immunol. 53:214.CrossRefGoogle Scholar
  29. Fowles, R. W., Fajardo, I. M., Lebowitch, J. L., and David, J. R., 1973, The enhancement of macrophage bacteriostasis by products of activated lymphocytes, J. Exp. Med. 138:952.PubMedCrossRefGoogle Scholar
  30. Fox, R. A., Gregory, D. S., and Feldman, J. D., 1974, Migration inhibition factor (MIF) and migration stimulation factor (MSF) in fetal calf serum, J. Immunol. 112:1861.PubMedGoogle Scholar
  31. Galindo, B., 1972, Antigen-mediated fusion of specifically sensitized rabbit alveolar macrophages, Infect. Immun. 5:583.PubMedGoogle Scholar
  32. Galindo, B., Lazdins, J., and Castillo, R., 1974, Fusion of normal rabbit alveolar macrophages induced by supernatants from BCG-sensitized lymph node cells after elicitation by antigens, Infect. Immun. 9:212.PubMedGoogle Scholar
  33. Geczy, C. L., and Hopper, K. E., 1981, A mechanism of migration inhibition in delayed-type hypersensitivity reactions. II. Lymphokines promote procoagulant activity of macrophages in vitro, J. Immunol. 126:1059.PubMedGoogle Scholar
  34. Godal, T., Rees, R. J. W., and Lamvick, J. O., 1971, Lymphocyte-mediated modification of bloodderived macrophage function in vitro: Inhibition of growth of intracellular mycobacteria with lymphokines, Clin. Exp. Immunol. 8:625.PubMedGoogle Scholar
  35. Greineder, D. K., Connorton, K. J., and David, J. R., 1979, Plasminogen activator production by human monocytes. I. Enhancement by activated lymphocytes and lymphocyte products, J. Immunol. 123:2808.PubMedGoogle Scholar
  36. Griffin, F. M., Jr., and Griffin, J. A., 1980, Augmentation of macrophage complement receptor function in vitro. II. Characterization of the effects of a unique lymphokine upon the phagocytic capabilities of macrophages, J. Immunol. 125:844.PubMedGoogle Scholar
  37. Griffin, J. A., and Griffin, F. M. Jr., 1979, Augmentation of macrophage complement receptor function in vitro I. Characterizations of the cellular interactions required for the generation of a T lymphocyte product which enhances macrophage complement receptor function. J. Exp. Med. 150:653.PubMedCrossRefGoogle Scholar
  38. Hadden, J. W., Sadlik, J. R., and Hadden, E. M., 1975, Macrophage proliferation induced in vitro by a lymphocyte factor, Nature (London) 257:483.CrossRefGoogle Scholar
  39. Hammond, M. E., and Dvorak, H. F., 1972, Antigen-induced stimulation of glucosamine incorporation by guinea pig peritoneal macrophages in delayed hypersensitivity, J. Exp. Med. 136:1518.PubMedCrossRefGoogle Scholar
  40. Hammond, M. E., Sekvagguim, S. S., and Dvorak, H. F., 1975, Antigen-enhanced glucosamine incorporation by peritoneal macrophages in cell-mediated hypersensitivity, J. Immunol. 115:914.PubMedGoogle Scholar
  41. Henney, C. S., Gaffney, J., and Bloom, B. R., 1974, On the relation of products of activated lymphocytes to cell-mediated cytolysis, J. Exp. Med. 140:837.PubMedCrossRefGoogle Scholar
  42. Hibbs, J. B., Taintor, R. R., Chapman, N. A., and Weinberg, J. B., 1977, Macrophage tumor killing influence of the local environment, Science 197:279.PubMedCrossRefGoogle Scholar
  43. Higgins, T. J., Sabatino, A. P., Remold, H. F., and David, J. R., 1978, Possible role of macrophage glycolipids as receptors for migration inhibitory factor (MIF), J. Immunol. 121:880.PubMedGoogle Scholar
  44. Keisari, T., and Pick, E., 1980, Lymphokine mimicry by PMA and the ionophore A23187: A new hypothesis for explaining the action mechanism of migration inhibitory factor, in: Biochemical Characterization of Lymphokines (A. de Weck, ed.), p. 113, Academic Press, New York.Google Scholar
  45. Klimentzek, V., and Sorg, C., 1977, Lymphokine-induced secretion of plasminogen activation by murine macrophages, Eur. J. Immunol 7:185.CrossRefGoogle Scholar
  46. Kniep, E. M., Domzig, W., Lohmann-Matthes, M., and Kickhofen, B., 1981, Partial purification and chemical characterization of macrophage cytotoxicity factor (MCF, MAF) and its separation from migration inhibitory factor (MIF), J. Immunol. 127:417.PubMedGoogle Scholar
  47. Kotkes, P., and Pick, E., 1977, New approaches to the characterization of guinea pig macrophage migration inhibitory factor, Isr. J. Med. Sci. 13:1045.Google Scholar
  48. Kotkes, P., and Pick, E., 1979, Purification of MIF after treatment with reducing and denaturing agents, Clin. Exp. Immunol. 37:540.PubMedGoogle Scholar
  49. Krahenbuhl, J. L., and Remington, J. S., 1971, In vitro introduction of non-specific resistance in macrophages by specifically sensitized lymphocytes, Infect. Immun. 4:337.PubMedGoogle Scholar
  50. Krahenbuhl, J. L., Rosenberg, L. T., and Remington, J. S., 1973, Role of T lymphocytes in the in vitro activation of macrophages to kill Listeria monocytogenes, J. Immunol. 111:992.Google Scholar
  51. Leu, R. W., Eddeston, A., Hadden, J. W., and Good, R. A., 1972, Mechanism of action of migration inhibitory factor (MIF), J. Exp. Med. 136:589.PubMedCrossRefGoogle Scholar
  52. Littman, B. H., and Ruddy, S., 1977, Production of the second component of complement by human monocytes: Stimulation by antigen-activated lymphocytes of lymphokines, J. Exp. Med. 145:1344.PubMedCrossRefGoogle Scholar
  53. Liu, D. Y., Petschek, K. D., Remold, H. G., and David, J. R., 1980, Role of sialic acid in the macrophage glycolipid receptor for MIF, J. Immunol. 124:2042.PubMedGoogle Scholar
  54. Lohmann-Matthes, M. L., Ziegler, F. G., and Fisher, H., 1973, Macrophage toxicity factor: A product of in vitro sensitized thymus-dependent cells, Eur. J. Immunol. 3:56.PubMedCrossRefGoogle Scholar
  55. Lolekha, S., Dray, S., and Gotoff, S. P., 1970, Macrophage aggregation in vitro: A correlation of delayed hypersensitivity, J. Immunol. 104:296.PubMedGoogle Scholar
  56. McAdam, K. P. W. J., and Dinarello, C. A., 1980, Induction of serum amyloid A-synthesis by human leukocyte pyrogen, in: Bacterial Endotoxins and Host Response (M. K. Agarwal, ed.), p. 167, Elsevier/North-Holland, Amsterdam.Google Scholar
  57. Manheimer, S., and Pick, E., 1973, The mechanism of action of soluble lymphocytic mediators, Immunology 24:1027.PubMedGoogle Scholar
  58. Meade, C. J., Ladmann, P. J., and Brenner, S., 1974, A sensitive assay for cellular hypersensitivity based on the uptake of radioactive colloidal gold, Immunology 27:227.PubMedGoogle Scholar
  59. Meltzer, M. S., 1981, Macrophage activation for tumor cytotoxicity: Characterization of priming and trigger signals during lymphokine activation, J. Immunol. 127:177.Google Scholar
  60. Mizoguchi, Y., Yamamoto, S., and Morisawa, S., 1973, Studies on the biosynthesis of macrophage migration inhibitory factor in delayed hypersensitivity, J. Biochem. 73:467.PubMedGoogle Scholar
  61. Nacy, C. A., Leonard, E. J., and Meltzer, M. S., 1981, Macrophages in resistance to rickettsial infections: Characterization of lymphokines that induce rickettsiacidal activity in macrophages, J. Immunol. 126:204.PubMedGoogle Scholar
  62. Nathan, C. F., Karnovsky, M. L., and David, J. R., 1971, Alterations of macrophage functions by mediators from lymphocytes, J. Exp. Med. 133:1356.PubMedCrossRefGoogle Scholar
  63. Nathan, C. F., Remold, H. G., and David, J. R., 1973, Characterization of a lymphocyte factor which alters macrophage functions, J. Exp. Med. 137:275.PubMedCrossRefGoogle Scholar
  64. Neta, R., and Salvin, S. B., 1971, Cellular immunity in vitro: Migration inhibition and phagocytosis, Infect. Immun. 4:697.PubMedGoogle Scholar
  65. Pantalone, R. M., and Page, R. C., 1975, Lymphokine-induced production and release of lysosomal enzymes by macrophages, Proc. Natl. Acad. Sci. USA 72:2091.PubMedCrossRefGoogle Scholar
  66. Pantalone, R. M., and Page, R. C., 1977, Enzyme production and secretion by lymphokine-activated macrophages, J. Reticuloendothelial Soc. 21:343.Google Scholar
  67. Patterson, R. J., and Youmans, G. P., 1970, Demonstration in tissue culture of lymphocyte mediated immunity to tuberculosis, Infect. Immun. 1:600.PubMedGoogle Scholar
  68. Pekarek, J., Svejcar, J., Monza, K., and Johanovsky, J., 1976, Effect of immunosuppressive drugs on an in vitro correlate of cell-mediated immunity, Immunology 31:773.PubMedGoogle Scholar
  69. Pels, E., and Den-Otter, W., 1974, The role of a cytophilic factor from challenged immune peritoneal lymphocytes in specific macrophage cytotoxicity, Cancer Res. 34:3089.PubMedGoogle Scholar
  70. Pick, E., 1974, Soluble lymphocytic mediators. I. Inhibition of macrophage migration inhibitory factor production by drugs, Immunology 26:649.PubMedGoogle Scholar
  71. Pick, E., 1977, Lymphokines: Physiologic control and pharmacological modulation of their production and action, in: Immunopharmacology (J. W. Hadden and R. G. Coffey, eds.), p. 163, Plenum Press, New York.CrossRefGoogle Scholar
  72. Pick, E., and Abrahamer, H., 1973, Blocking of macrophage migration inhibitory factor action by microtubular disruptive drugs, Int. Arch. Allergy Appl. Immunol. 45:295.PubMedCrossRefGoogle Scholar
  73. Pick, E., and Grunspan-Swirsky, A., 1977, The mechanism of action of soluble lymphocyte mediators, Cell. Immunol. 32:340.PubMedCrossRefGoogle Scholar
  74. Piessens, W. F., Churchill, W. H., and David, J. R., 1975, Macrophages activated in vitro with lymphocyte mediators kill neoplastic but not normal cells, J. Immunol. 114:293.PubMedGoogle Scholar
  75. Poste, G., and Kirsch, R., 1979, Rapid decay of tumoricidal activity and loss of responsiveness to lymphokines in inflammatory macrophages, Cancer Res. 39:2582.PubMedGoogle Scholar
  76. Poulter, L. W., and Turk, J. L., 1975, Studies on the effect of soluble lymphocyte products on macrophage physiology, Cell. Immunol. 20:25.PubMedCrossRefGoogle Scholar
  77. Remold, H. G., 1973, Requirement for a-L-fucose on the macrophage membrane receptor for MIF, J. Exp. Med. 138:1065.PubMedCrossRefGoogle Scholar
  78. Remold, H. G., 1977, Chemical treatment of macrophages increases their responses to migration inhibitory factor, J. Immunol. 118:1.PubMedGoogle Scholar
  79. Remold, H. G., and Mednis, A., 1975, Decrease of three lysosomal enzymes in guinea pig macrophages activated by lymphocyte mediators, Inflammation 1:175.CrossRefGoogle Scholar
  80. Remold, H. G., and Mednis, A., 1977, Two migration inhibitory factors with different chro-matographic behavior and isoelectric points, J. Immunol. 118:2015.PubMedGoogle Scholar
  81. Remold, H. G., and Rosenberg, R. D., 1975, Enhancement of migration inhibitory factor activity by plasma esterase inhibitors, J. Biol. Chem. 250:6608.PubMedGoogle Scholar
  82. Remold, H. G., David, R. A., and David, J. R., 1972, Characterization of migration inhibitory factor (MIF) from guinea pig lymphocytes stimulated with concanavalin A, J. Immunol. 109:578.PubMedGoogle Scholar
  83. Remold, H. G., Shaw, J. E., and David, J. R., 1981, A macrophage surface component related to fibronectin is involved in the response to migration inhibitory factor, Cell. Immunol. 58:175.PubMedCrossRefGoogle Scholar
  84. Remold-O’Donnell, E., and Remold, H. G., 1974, The enhancement of macrophage adenylate cyclase by products of stimulated lymphocytes, J. Biol. Chem. 249:3622.PubMedGoogle Scholar
  85. Rocklin, R. E., 1973, Production of macrophage migration inhibitory factor by nondividing lymphocytes, J. Immunol. 110:674.PubMedGoogle Scholar
  86. Rocklin, R. E., 1976, Role of monosaccharides in the interaction of two lymphocyte mediators with their target cells, J. Immunol. 116:816.PubMedGoogle Scholar
  87. Rocklin, R. E., Winston, C. T., and David, J. R., 1974, Activation of human blood monocytes by products of sensitized lymphocytes, J. Clin. Invest. 53:559.PubMedCrossRefGoogle Scholar
  88. Rosenwasser, L. J., Dinarello, C. A., and Rosenthal, A. S., 1979, Adherent cell function in murine Tlymphocyte antigen recognition. IV. Enhancement of murine T-cell antigen recognition by human leukocytic pyrogen, J. Exp. Med. 150:709.PubMedCrossRefGoogle Scholar
  89. Scher, M. G., Beller, D. I., and Unanue, E. R., 1980, Demonstration of a soluble mediator that induces exudates rich in Ia-positive macrophages, J. Exp. Med. 152:1684.PubMedCrossRefGoogle Scholar
  90. Sharma, S. D., Piessens, W. F., and Middlebrook, G., 1980, In vitro killing of tumor cells by soluble products of activated guinea pig peritoneal macrophages, Cell. Immunol. 49:379.PubMedCrossRefGoogle Scholar
  91. Shubert, R. D., and David, J. R., 1980, Stimulation of guinea pig macrophage pinocytosis by lipoplysaccharides (LPS): Evidence that LPS acts directly on the macrophage, Cell. Immunol. 55:166.CrossRefGoogle Scholar
  92. Shubert, R. D., Wong, J., and David, J. R., 1980, Stimulation of pinocytosis in the macrophage by lymphocyte mediators. II. Evidence that the stimulating factor is MAF, and studies on the cellular requirements for response to the mediator, Cell. Immunol. 55:155.CrossRefGoogle Scholar
  93. Smyth, A. C., and Weiss, L., 1970, Electron microscopic study of inhibition of macrophage migration in delayed hypersensitivity, J. Immunol. 105:1360.PubMedGoogle Scholar
  94. Snyderman, R., Meadows, L., and Amos, D. B., 1977, Characterization of human chemotactic lymphokine production induced by mitogens and mixed leukocyte reactions using a new microassay, Cell. Immunol. 30:225.PubMedCrossRefGoogle Scholar
  95. Sorg, C., and Bloom, B. R., 1973, Products of activated lymphocytes. I. The use or radiolabelling techniques in the characterization and partial purification of the migration inhibitory factor of the guinea pig, J. Exp. Med. 137:148.PubMedCrossRefGoogle Scholar
  96. Svejcar, J., and Johanovsky, J., 1961, Demonstration of delayed type hypersensitivity in vitro. II. Specific reaction of hypersensitive cells with antigens, Z. Immunitaetsforsch. 122:420.PubMedGoogle Scholar
  97. Taffet, S. M., Pace, J. L., and Russell, S. W., 1981, Lymphokine maintains macrophage activation for tumor cell killing by interfering with the negative regulatory effect of prostaglandin E2, J. Immunol. 127:121.PubMedGoogle Scholar
  98. Taramelli, D., Holden, H. T., and Varesio, L., 1981, In vitro induction of tumoricidal and suppressor macrophages by lymphokines: Possible feedback regulation, J. Immunol. 126:2123.PubMedGoogle Scholar
  99. Thrasher, S. G., Yoshida, T., van Oss, C. J., Cohen, S., and Rose, N. R., 1973, Alteration of macrophage interfacial tension by supernatants of antigen-activated lymphocytes, J. Immunol. 110:321.PubMedGoogle Scholar
  100. Unsgaard, G., 1979, Cytostatic and phagocytic capacity of lymphokine-activated human monocytes, Acta Pathol. Microbiol. Scand. Sect. C 87:325.Google Scholar
  101. Vassalli, J., and Reich, E., 1977, Macrophage plasminogen activation: Induction by products of activated lymphoid cells, J. Exp. Med. 145:429.PubMedCrossRefGoogle Scholar
  102. Wahl, L. M., Wahl, S. M., Mergenhagen, S. E., and Martin, G. R., 1975, Collagenase production by lymphokine-activated macrophages, Science 187:261.PubMedCrossRefGoogle Scholar
  103. Washl, S. M., Iverson, G. M., and Oppenheim, J. J., 1974, Induction of B cell guinea pig lymphokine synthesis by mitogenic and non-mitogenic signals, J. Exp. Med. 140:1631.CrossRefGoogle Scholar
  104. Ward, P. A., and Rocklin, R. E., 1975, Production by antigen-stimulated human lymphoid cells of a monocyte chemotactic factor, in: The Immune System and Infectious Disease (E. Neter and F. Milgrom, eds.), p. 470, Karger, Basel.Google Scholar
  105. Ward, P. A., Remold, H. G., and David, J. R., 1969, Leukotactic factor produced by sensitized lymphocytes, Science 163:1079.PubMedCrossRefGoogle Scholar
  106. Weisbart, R. H., Bluestone, R., Goldberg, L. S., and Pearson, C. M., 1974, Migration enhancement factor: A new lymphokine, Proc. Natl. Acad. Sci USA 74:875.CrossRefGoogle Scholar
  107. Weiser, W. Y., Greineder, D. K., Remold, H. G., and David, J. R., 1981, Studies on human migration inhibitory factor: Characterization of three molecular species, J. Immunol. 126:1958.PubMedGoogle Scholar
  108. Wilton, J. M., Rosenstreich, D. L., and Oppenheim, J. J., 1975, Activation of guinea pig macrophages by bacterial lipopolysaccharide requires bone-marrow derived lymphocytes, J. Immunol. 114:388.PubMedGoogle Scholar
  109. Yoshida, T., and Reisfeld, R., 1970, Two fractions with macrophage migration inhibitory activity from sensitized lymphocyte cultures, Nature (London) 226:856.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Ross Rocklin
    • 1
  1. 1.Allergy Division, Department of Medicine, New England Medical CenterTufts University School of MedicineBostonUSA

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