The Clinical Course of Renal Disease in Caucasian NIDDM Patients

  • Søren Nielsen
  • Anita Schmitz

Abstract

Diabetic nephropathy is now the most prevalent cause of end-stage renal disease (ESRD) in the Western world [1], accounting for approximately 30% of all patients entering end-stage renal failure programs [2]. Albeit diabetes is the single most important cause of ESRD in the United States [3], the percentage of patients with diabetes requiring renal replacement therapy in the European population is somewhat lower [4], about 13% leaving glomerulonephritis and renal vascular disease due to hypertension as the most frequent causes of ESRD [5]. Approximately one-half of the diabetes related ESRD occur in NIDDM patients [6,7].

Keywords

Glomerular Filtration Rate Diabetic Nephropathy Renal Replacement Therapy Diabetes Duration Albumin Excretion Rate 
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References

  1. 1.
    FitzSimmons SC, Agodoa L, Striker L, Conti F, Striker G. Kidney disease of diabetes mellitus: NIDDK initiatives for the comprehensive study of its natural history, pathogenesis, and prevention. Am J Kidney Dis 1989; 8:7–10.Google Scholar
  2. 2.
    Eggers PW. Effect of transplantation on the medicare end-stage renal disease program. N Engl J Med 1993; 381:223–229Google Scholar
  3. 3.
    Walker WG. Hypertension-related renal injury: a major contributor to end-stage renal disease. Am J Kidney Dis 1993; 22:164–173PubMedGoogle Scholar
  4. 4.
    Raine AEG. Epidemiology, development and treatment of end-stage renal failure in Type 2 (non-insulin-dependent) diabetic patients in Europe. Diabetologia 1993; 36:1099–1104PubMedCrossRefGoogle Scholar
  5. 5.
    Bnmner FP, Selwood NH. Profile of patients on RRT in Europe and death rates due to major causes of death groups. Kidney Int 1992; 42 Suppl. 38: S4–S15Google Scholar
  6. 6.
    Rettig B, Teutsch SM. The incidence of end-stage renal disease in type II and type II diabetes mellitus. Diabetic Nephropathy 1984; 3: 26–27Google Scholar
  7. 7.
    Grenfell A, Bewick M, Parsons V, Snowden S, Taube D, Watkins PI Non-insulin-dependent diabetes and renal replacement therapy. Diabetic Med 1988; 5:172–176PubMedCrossRefGoogle Scholar
  8. 8.
    Mogensen CE, Damsgaard EM, Frøland A, Nielsen S, de Fine Olivarius N, Schmitz A. Microalbuminuria in non- insulin-dependent diabetes. Clin Nephrology 1992; 38 Suppl. 1: S28–S38Google Scholar
  9. 9.
    Mogensen CE. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med 1984; 310: 356–360PubMedCrossRefGoogle Scholar
  10. 10.
    Jarrett RJ, Viberti GC, Argyropoulos A, Hill RD, Mahmud U, Murrells TJ. Microalbuminuria predicts mortality in non-insulin-dependent diabetics. Diabetic Med 1984; 1:17–19PubMedCrossRefGoogle Scholar
  11. 11.
    Schmitz A, Vaeth M. Microalbuminuria: a major risk factor in non-insulin-dependent diabetes. A 10-year follow-up study of 503 patients. Diabetic Med 1988; 5: 126–134PubMedCrossRefGoogle Scholar
  12. 12.
    Stephenson JM, Kenny S, Stevens LK, Fuller JH, Lee E. Proteinuria and mortality in diabetes: the WHO multinational study of vascular disease in diabetes. Diabetic Med 1995; 12:149–155PubMedCrossRefGoogle Scholar
  13. 13.
    Nelson RG, Pettitt DJ, Carraher MJ, Baird HR, Knowler WC. Effect of proteinuria on mortality in NIDDM. Diabetes 1988; 37: 1499–1504PubMedCrossRefGoogle Scholar
  14. 14.
    Bröchner-Mortensen J. A simple method for the determination of glomerular filtration rate. Scand J Clin Lab Invest 1972; 30: 271–274PubMedCrossRefGoogle Scholar
  15. 15.
    Bröchner-Mortensen J, Rødbro P. Selection of routine method for determination of glomerular filtration rate in adult patients. Scand J Clin Lab Invest 1976; 36: 35–43PubMedCrossRefGoogle Scholar
  16. 16.
    Mogensen CE, Hansen KW, Nielsen S, Mau Pedersen M, Rehling M, Schmitz A. Monitoring diabetic nephropathy: Glomerular filtration rate and abnormal albuminuria in diabetic renal disease — reproducibility, progression, and efficacy of antihypertensive intervention. AM J Kidney Dis 1993; 22: 174–187PubMedGoogle Scholar
  17. 17.
    Vora JP, Dolben J, Dean JD, Thomas D, Williams JD, Owens DR, Peters JR. Renal hemodynamics in newly presenting non-insulin dependent diabetes mellitus. Kidney Int 1992; 41: 829–835.PubMedCrossRefGoogle Scholar
  18. 18.
    Schmitz A, Hansen HH, Christensen T. Kidney function in newly diagnosed type 2 (non-insulin-dependent) diabetic patients, before and during treatment Diabetologia 1989; 32:434–439.PubMedCrossRefGoogle Scholar
  19. 19.
    Keller CK, Bergis KH, Fliser D, Ritz E. Renal findings in patients with short-term type 2 diabetes. J Am Soc Nephrol 1996; 7: 2627–2635.PubMedGoogle Scholar
  20. 20.
    Damsgaard EM, Mogensen CE. Microalbuminuria in elderly hyperglycaemic patients and controls. Diabetic Med 1986; 3: 430–435.PubMedCrossRefGoogle Scholar
  21. 21.
    Vora JP, Dolben J, Williams JD, Peters JR, Owens DR. Impact of initial treatment on renal function in newly-diagnosed Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1993; 36: 734–740.PubMedCrossRefGoogle Scholar
  22. 22.
    Wirta O, Pastemack A, Mustonen J, Oksa H, Koivula T, Helin H. Albumin excretion rate and its relation to kidney disease in non-insulin-dependent diabetes mellitus. J Intern Med 1995; 237: 367–373.PubMedCrossRefGoogle Scholar
  23. 23.
    Schmitz A, Christensen T, Jensen FT. Glomerular filtration rate and kidney volume in normoalbuminuric non-insulin-dependent diabetics — lack of glomerular hyperfiltration and renal hypertrophy in uncomplicated NIDDM. Scand J Clin Lab Invest 1989; 48: 103–108.CrossRefGoogle Scholar
  24. 24.
    Schmitz A, Christensen T, Moller A, Mogensen CE. Kidney function and cardiovascular risk factors in non-insulin-dependent diabetics (NIDDM) with microalbuminuria. J Intern Med 1990; 228: 347–352.PubMedCrossRefGoogle Scholar
  25. 25.
    Savage S, Nagel NJ, Estacio RO, Lukken N, Schrier RW. Clinical factors associated with urinary albumin excretion in type II diabetes. Am J Kidney Dis 1995; 25: 836–844.PubMedCrossRefGoogle Scholar
  26. 26.
    Wirta O, Pasternack A, Laippala P, Turjanmaa V. Glomerular filtration rate and kidney size after six years disease duration in non-insulin-dependent diabetic subjects. Clin Nephrol 1996; 45:10–17.PubMedGoogle Scholar
  27. 27.
    Fahre J, Balant LP, Dayer PG, Fox HM, Vernet AT. The kidney in maturity onset diabetes mellitus: A clinical study of 510 patients. Kidney Int 1982; 21:730–738.CrossRefGoogle Scholar
  28. 28.
    Gragnoli G, Signorini AM, Tanganelli I, Fondelli C, Borgogni P, Borgogni L, Vattimo A, Ferrari F, Guercia M. Prevalence of glomerular hyperfiltration and nephromegaly in normo- and microalbuminurictype 2 diabetic patients. Nephron 1993; 65:206–211.PubMedCrossRefGoogle Scholar
  29. 29.
    Wirta OR, Pastemack AI. Glomerular filtration rate and kidney size in type 2 (non-insulin-dependent) diabetes mellitus. Clin Nephrol 1995; 44:1–7.PubMedGoogle Scholar
  30. 30.
    Silveiro SP, Friedman R, Gross JL Glomerular hyperfiltration in NIDDMpatients without overt proteinuria. Diabetes Care 1993; 16:115–119.PubMedCrossRefGoogle Scholar
  31. 31.
    Nowack R, Raum E, Blum W, Ritz E. Renal hemodynamics in recent-onset type II diabetes. Am J Kidney Dis 1992; 20:342–347.PubMedGoogle Scholar
  32. 32.
    Vedel P, Obel J, Nielsen FS, Bang LE, Svendsen TL, Pedersen OB, Parving HH. Glomerular hyperfiltration in microalbuminuric NIDDM patients. Diabetologia 1996; 39:1584–1589PubMedCrossRefGoogle Scholar
  33. 33.
    Rius F, Pizarro E, Castells I, Salinas I, Sanmarti A, Romero R. Renal function changes in hypertensive patients with non-insulin-dependent diabetes mellitus. Kidney Int 1996; 55 Suppl: S88–S90.Google Scholar
  34. 34.
    Rius F, Pizaro E, Salinas I, Lucas A, Sanmarti A, Romero R. Age as a determinant of glomerular filtration rate in non-insulin-dependent diabetes mellitus. Nephrol Dial Transplant 1995; 10: 1644–1647.PubMedGoogle Scholar
  35. 35.
    Nielsen S, Schmitz A, Rehling M, Mogensen CE. Systolic blood pressure relates to the rate of decline of glomerular filtration rate in Type 2 diabetes mellitus. Diabetes Care 1993; 16: 1427–1432.PubMedCrossRefGoogle Scholar
  36. 36.
    Silveiro SP, Friedman R, De Azevedo MJ, Canani LH, Gross JL. Five-year prospective study of glomerular filtration rate and albumin excretion rate in normofiltering and hyperfiltering normoalbuminuric NIDDM patients- Diabetes Care 1996; 19: 171–174.PubMedCrossRefGoogle Scholar
  37. 37.
    Gall M-A, Nielsen FS, Smidt UM, Parving H-H. The course of kidney function in Type 2 (non-insulin-dependent) diabetic patients with diabetic nephropathy. Diabetologia 1993; 36:1071–1078.PubMedCrossRefGoogle Scholar
  38. 38.
    Rowe JW, Andres R, Tobin JD, Norris AH, Shock NW. The effect of age on creatinine clearance in men: A cross-sectional and longitudinal study. J Gerontology 1976; 31: 155–163.CrossRefGoogle Scholar
  39. 39.
    Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stem MP. Prospective analysis of the insulin-resistance syndrome (Syndrome X). Diabetes 1992; 41: 715–722.PubMedCrossRefGoogle Scholar
  40. 40.
    Nielsen S, Schmitz A, Rehling M, Mogensen CE. The clinical course of renal function in NIDDM patients with normo- and microalbuminuria. J Intern Med 1997; 241:133–141.PubMedCrossRefGoogle Scholar
  41. 41.
    Nielsen S, Schmitz A, Derkx FHM, Mogensen CE. Prorenin and renal function in NIDDM patients with normo- and microalbuminuria. J Intern Med 1995; 238:499–505.PubMedCrossRefGoogle Scholar
  42. 42.
    Ravid M, Savin H, Lang R, Jutrin I, Shoshana L, Lishner M. Proteinuria, renal impairment, metabolic control, and blood pressure in type 2 diabetes mellitus. Arch Intern Med 1992; 152: 1225–1229.PubMedCrossRefGoogle Scholar
  43. 43.
    Stornello M, Valvo EV, Scapellato L. Angiotensin converting enzyme inhibition in normotensive type II diabetics with persistent mild proteinuria. J Hypertens 1989; 7 Suppl 6:314–315.Google Scholar
  44. 44.
    Biesenbach G, Janko O, Zazgornik J. Similar rate of progression in the predialysis phase in type I and type II diabetes mellitus. Nephrol Dial Transplant 1994; 9:1097–1102.PubMedGoogle Scholar
  45. 45.
    Ravid M, Savin H, Jutrin I, Bental T, Katz B, Lishner M. Long-term stabilizing effect of angiotensin-converting enzyme inhibition on plasma creatinine and on proteinuria in normotensive type II diabetic patients. Ann Intern Med 1993; 118: 577–581.PubMedCrossRefGoogle Scholar
  46. 46.
    Melbourne Diabetic Nephropathy Study Group. Comparison between Perindopril and nifedipine in hypertensive and normotensive diabetic patients with microalbuminuria. BMJ 1991; 302: 210–216.CrossRefGoogle Scholar
  47. 47.
    Gambardella S, Frontoni S, Lala A, Felici MG, Spallone V, Scoppola A, Jacoangeli F, Menzinger G. Regression of microalbuminuria in type II diabetic hypertensive patients after long-term indapamide treatment. Am Heart J 1991; 122: 1232–1238.PubMedCrossRefGoogle Scholar
  48. 48.
    Lacourcière Y, Nadeau A, Poirier L, Tancrède G. Captopril or conventional therapy in hypertensive type II diabetics.Three-year analysis. Hypertension 1993; 21: 786–794.PubMedCrossRefGoogle Scholar
  49. 49.
    Ravid M, Lang R, Rachmani R, Lishner M Long-term renoprotective effect of angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. A 7-year follow-up study. Arch Intern Med 1996; 156:286–289.PubMedCrossRefGoogle Scholar
  50. 50.
    Velussi M, Brocco E, Frigato F, Zolli M, Muollo B, Maioli M, Carraro A, Tonolo G, Fresu P, Cernigoi AM, Fioretto P, Nosadini R. Effects of Cilazapril and amlodipine on kidney function in hypertensive NIDDM patients. Diabetes 1996; 45: 216–222.PubMedCrossRefGoogle Scholar
  51. 51.
    Ruggenenti P, Mosconi L, Bianchi L, Cortesi L, Campana M, Pagani G, Mecca G, Remuzzi G. Long-term treatment with either enalapril or nitrendipine stabilizes albuminuria and increases glomerular filtration rate in non-insulin- dependent diabetic patients. Am J Kidney Dis 1994; 24: 753–761.PubMedGoogle Scholar
  52. 52.
    Mosconi L, Ruggenenti P, Pema A, Mecca G, Remuzzi G. Nitrendipine and enalapril improve albuminuria and glomerular filtration rate in non-insulin dependent diabetes. Kidney International 1996; 55 Suppl: S91–S93.Google Scholar
  53. 53.
    Valvo E, Bedogna V, Casagrande P, Antiga L, Zamboni M, Bommartini F, Oldrizzi L, Rugiu C, Maschio G. Captopril in patients with type II diabetes and renal insufficiency: Systemic and renal hemodyna alterations. Am J Med 1988; 85: 344–348PubMedCrossRefGoogle Scholar
  54. 54.
    Nielsen FS, Rossing P, Gall M-A, Skøtt P, Smidt UM, Parving H-H. Impact of lisinopril and atenolol on kidney function in hypertensive NIDDM subjects with diabetic nephropathy. Diabetes 1994;43:1108–1113PubMedCrossRefGoogle Scholar
  55. 55.
    Nielsen FS, Rossing P, Gall MA, Skøtt P, Smidt UM, Parving HH. Long-term effect of lisinopril and atenolol on kidney function in hypertensive NIDDM subjects with diabetic nephropathy. Diabetes 1997; 46: 1182–1188.PubMedCrossRefGoogle Scholar
  56. 56.
    Stomello M, Valvo EV, Scapellato L. Persistent albuminuria in normotensive non-insulin-dependent (type II) diabetic patients: comparative effects of angiotensin-converting enzyme inhibitors and β-adrenoceptor blockers. Clin Sci 1992; 82: 19–23Google Scholar
  57. 57.
    Moorhead JF, Chan MK, El-Nahas M, Varghese Z.Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease. Lancet 1982; 1309–1311Google Scholar
  58. 58.
    Kostner GM, Karadi I. Lipoprotein alterations in diabetes mellitus. Diabetologia 1988; 31: 717–722PubMedCrossRefGoogle Scholar
  59. 59.
    Niskanen L, Uusitupa M, Sarlund H, Siitonen O, Voutilainen E, Penttilä I, Pyörälä K. Microalbuminuria predicts the development of serum lipoprotein abnormalities favouring atherogenesis in newly diagnosed type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1990; 33: 237–43ISPubMedCrossRefGoogle Scholar
  60. 60.
    Nielsen S, Schmitz O, Møller N, Pørksen N, Klausen IC, Alberti KGMM, Mogensen CE. Renal function and insulin sensitivity during simvastatin treatment in Type 2 (non-insulin-dependent) diabetic patients with microalbuminuria. Diabetologia 1993; 36:1079–1086PubMedCrossRefGoogle Scholar
  61. 61.
    Ritz E, Stefanski A. Diabetic nephropathy in type II diabetes. American Journal of Kidney Diseases 1996; 27: 167–194.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1998

Authors and Affiliations

  • Søren Nielsen
    • 1
  • Anita Schmitz
    • 1
  1. 1.Medical Department MAarhus KommunehospitalAarhusDenmark

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