The Role of Growth Factors in Diabetic Kidney Disease

  • Allan Flyvbjerg
  • Henning Grønbæk
  • Martin Bak
  • Birgitte Nielsen
  • Thora Christiansen
  • Ida Vogel
  • Hans Ørskov

Abstract

Growth factors have attracted attention in several areas of diabetes research including conceivable effects on the renal changes seen in experimental and human diabetes. In our review article published in The Kidney and Hypertension in Diabetes Mellitus, Second Edition, 1994 we covered the published evidence for a connection between changes in various growth factors (growth hormone (GH), insulin-like growth factors (IGFs), epidermal growth factor (EGF), transforming growth factor β (TGF-β), platelet derived growth factor (PDGF), tumor necrosis factor α (TNF-α) and fibroblastic growth factors (FGFs)) and the development of renal changes in diabetes. Almost every month there are several new papers on the possible relationship between growth factors and the development of diabetic nephropathy, which makes it progressively more difficult to write an ‘up-to-date’ review on the topic, and not all papers can be discussed in detail here.

Keywords

Urinary Albumin Excretion Diabetic Kidney Disease Diabetes Induction Renal Hypertrophy Octreotide Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Allan Flyvbjerg
    • 1
  • Henning Grønbæk
    • 1
  • Martin Bak
    • 1
  • Birgitte Nielsen
    • 1
  • Thora Christiansen
    • 1
  • Ida Vogel
    • 1
  • Hans Ørskov
    • 1
  1. 1.Medical Research Laboratories, Institute of Experimental Clinical ResearchUniversity Hospital, Aarhus KommunehospitalAarhusDenmark

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