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Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors

  • Jiten P. Vora
  • Sharon Anderson
  • Barry M. Brenner
Chapter

Abstract

Glomerular hyperfiltration in insulin-dependent (type 1) diabetes mellitus (IDDM) has been recognized for many years [1–3], with increments in renal plasma flow (RPF) and nephromegaly [3]. With the finding of hyperfiltration, Stalder and Schmid proposed that these early functional changes may predispose the subsequent development of diabetic glomerulopathy [1]. Early support for the hypothesis that renal hyperperfusion and hyperfiltration contribute to diabetic glomerulopathy emanated from the finding of diabetic glomerulopathy only in the non-stenosed kidney in the setting of unilateral renal artery stenosis [4].

Keywords

Atrial Natriuretic Peptide Experimental Diabetes Renal Plasma Flow Glomerular Hyperfiltration Tubuloglomerular Feedback 
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© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Jiten P. Vora
  • Sharon Anderson
  • Barry M. Brenner

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