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Pathogenesis of Diabetic Glomerulopathy: The Role of Glomerular Hemodynamic Factors

  • Jiten P. Vora
  • Sharon Anderson
  • Barry M. Brenner

Abstract

Glomerular hyperfiltration in insulin-dependent (type 1) diabetes mellitus (IDDM) has been recognized for many years [1–3], with increments in renal plasma flow (RPF) and nephromegaly [3]. With the finding of hyperfiltration, Stalder and Schmid proposed that these early functional changes may predispose the subsequent development of diabetic glomerulopathy [1]. Early support for the hypothesis that renal hyperperfusion and hyperfiltration contribute to diabetic glomerulopathy emanated from the finding of diabetic glomerulopathy only in the non-stenosed kidney in the setting of unilateral renal artery stenosis [4].

Keywords

Atrial Natriuretic Peptide Experimental Diabetes Renal Plasma Flow Glomerular Hyperfiltration Tubuloglomerular Feedback 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Jiten P. Vora
  • Sharon Anderson
  • Barry M. Brenner

There are no affiliations available

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