Rhabdomyolysis is defined as disintegration or dissolution of striped muscle and, regardless of the etiology, results in myocyte death with the release of myoglobin into the systemic circulation. Accounts of rhabdomyolysis can be found as far back as the Old Testament, but Bywaters and Beall first associated crush injuries with dark urine, shock, and renal failure in patients who were bombing casualties during World War II (1). Since that time, rhabdomyolysis has become recognized as one of the most common causes of acute renal failure (ARF) in the United States, with the estimated risk of ARF following rhabdomyolysis ranging from 4% to 33% (2–4).
KeywordsAcute Renal Failure Compartment Syndrome Crush Injury Volume Resuscitation Francisella Tularensis
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- 9.Boles JM. Rhabdomyolysis and compartment syndrome In: Webb AR, Shapiro MJ, Singer M, Suter PM (eds). Oxford Textbook of Critical Care, Oxford, Oxford University Press, 1999, 722725.Google Scholar