Pathogenesis and Treatment of Hypoosmolar and Hyperosmolar States

  • J. Carlos Ayus
  • Allen I. Arieff

Abstract

Under usual conditions, the osmolality of the extracellular fluid (ECF) is maintained within an extremely narrow range. When this range is exceeded, the cells of the body are subject to an injurious influx or efflux of water, which preserves uniform tonicity of all body fluids. Thus, in situations where the osmolality of body fluids is disturbed, the principal pathophysiology is related to the inability of cells to maintain normal volume (and hence structure and function). Of course, each of the somatic cells of the body has some ability to regulate its own volume; when this regulatory ability is exceeded, symptoms referable to hypoosmolality or hyperosmolality appear. Before discussing specific clinical syndromes of deranged plasma tonicity, it is appropriate to review some important aspects of cell volume regulation.

Keywords

Serum Sodium Plasma Osmolality Cell Volume Regulation Central Pontine Myelinolysis Water Intoxication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • J. Carlos Ayus
    • 1
  • Allen I. Arieff
    • 2
  1. 1.Baylor College of MedicineHoustonUSA
  2. 2.Geriatrics Research & Education San Francisco V.A. Medical CenterUniversity of California School of MedicineSan FranciscoUSA

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