Brain Glycoproteins and Inter-Cell Recognition: Tay-Sachs’ Disease and Intraneuronal Recognition

  • Samuel Bogoch
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)

Abstract

In earlier work we demonstrated that the carbohydrate abnormality in Tay-Sachs’ Disease was not confined to the brain gangliosides, but that there was in addition a generalized increase in glycoprotein hexose and hexosamine (4). One glycoprotein fraction, 10B, was found to be markedly increased in concentration. It was noted that this might be a function of the marked gliosis, since there was other evidence that 10B is a glial constituent. In that report, the information functions of the brain glycoproteins was proposed, and in related studies (summarized in reference 1) the general function of brain glycoproteins in intercell recognition was proposed (“Sign-Post” Theory).

Keywords

Brain Tumor Amino Sugar Glial Tumor Human Brain Tumor Brain Ganglioside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    BOGOCH, S., The Biochemistry of Memory; With An Inquiry Into the Function of the Brain Mucoids. Oxford University Press, New York, London, 1968.Google Scholar
  2. 2.
    BOGOCH, S. Glycoproteins of The Brain of the Training Pigeon: In: Symposium on Protein Metabolism of the Nervous System. Lajtha, A., Ed., Plenum Press, 1969, p. 555.Google Scholar
  3. 3.
    BOGOCH, S., Quantitative Studies of Brain Proteins in Disorders of the Nervous System and In Learning. In: Eighth International Congress of Neurology, International Congress Series, Constans, J. P., Gibberd, F. B. and Junze, K., Eds. Amsterdam: Excerpta Medical Foundation, 1965, p. 139.Google Scholar
  4. 4.
    BOGOCH, S. and BELVAL, P. Brain Proteins in the Sphingolipidoses: Tay-Sachs’ Disease Protein. In: Inborn Disorders of Sphingolipid Metabolism. Proceedings of the Third International Symposium on the Cerebral Sphingolipidoses. Aronson, S. and Volk, B. W., Eds. New York: Pergamon Press, 1966, p. 273Google Scholar
  5. 5.
    BOGOCH, S., SACKS, W.,SWEET, W. H., KORSH, G. and BELVAL, P. C. Structure of, and Incorporation of (14C) Glucose Into Isolated Protein and Carbohydrate Macromolecules of Brain Subcellular Membranous Components in Resting, Training and Tumor Brain Tissue. In: Protides of the Biological Fluids. Proceedings of the Fifteenth Colloquium, Bruges, 1966. Peeters, H., Ed., New York Elsevier Publishing Company, 1968, p. 129Google Scholar
  6. 6.
    BOGOCH, S., Proteins. In Handbook of Neurochemistry, Vol. 1, Lajtha, A., Ed, Plenum Press, 1969, p. 75.Google Scholar
  7. 7.
    WEISENBERG, R. C., BORISY, G. G., and TAYLOR, E. W. Biochemistry 1, 4466, 1968.CrossRefGoogle Scholar
  8. 8.
    MOORE, B. W. and McGREGOR, D., J. Biol. Chem. 240, 1647, 1965.Google Scholar
  9. 9.
    BENNETT, G. S. and EDELMAN, G. M., J. Biol, Chem. 243, 6234, 1968.Google Scholar
  10. 10.
    FALXA, M. L. and GILL, T. J. Arch. Biochem. and Biophys. 135 194, 1969.Google Scholar
  11. 11.
    QUAMINA, A., and BOGOCH, S., Subcellular Fractionation of Glycoproteins and Mucoids of Human and Rat Brain. In: Protides of the Biological Fluids. Proceedings of the Thirteenth Colloquium, Bruges, 1965. Peeters, H,, Ed., New York, Elsevier, 1966, p. 211Google Scholar
  12. 12.
    BOGOCH, S., RAJAM, P. C. and BELVAL, P. C. Nature 204, 73, 1964.CrossRefGoogle Scholar
  13. 13.
    BOGOCH, S., BOGOCH, E., KORSH, G. and DAS, B. R. unpublished results.Google Scholar
  14. 14.
    BENDA, P., MORI, T. and SWEET, W. H. J. Neurosurg. 33, 281–286, 1970.PubMedCrossRefGoogle Scholar
  15. 15.
    WOODBURY, D. M., TIMIRAS, P. S. and VERNADAKIS, A. Modification of Adrenocortical Function Centrally Acting Drugs and the Influence of Such Modification on the Central Response to these Drugs. In Hormones, Brain Function and Behavior. H. Hoagland, Ed., Academic, 1957, p. 3 8.Google Scholar
  16. 16.
    BRODDLE, W. D., and NELSON, S. R. Fed. Proc. 27, 751, 1968.Google Scholar
  17. 17.
    HUTCHINS, D. A. and ROGERS, K. J. Brit. J. Pharmacol. 39, 9, 1970.Google Scholar
  18. 18.
    BOGOCH, S., and DREYFUS, J. J. The Broad Range of Use of Diphenylhydantoin: Bibliography and Review. Dreyfus Medical Foundation, New York, 1970.Google Scholar
  19. 19.
    BOGOCH, S., Inverse Relationship Between Cell Replication and Macromolecular Carbohydrate Concentration: A Distance Factor (DF) in Brain Tumors. Abstracts, Third International Meeting of the International Society for Neurochemistry, Budapest, July 5–9, 1971.Google Scholar
  20. 20.
    JACOBSON, M., Develop. Biol. 17, 219, 1968.PubMedCrossRefGoogle Scholar
  21. 21.
    STOKER, M., and RUBIN, H., Nature 215, 171, 1967.PubMedCrossRefGoogle Scholar
  22. 22.
    BURGER, M. M., and GOLDBERG, A. R. Proc. Natnl. Acad. Sci. U. S. 57, 359, 1967.Google Scholar
  23. 23.
    KOREY, S. and TERRY, R. D. J. Neuropath. Exp. Neurol. 22, 2, 1963.Google Scholar
  24. 24.
    BOGOCH, S., Brain Glycoprotein 10B: Further Evidence on the “Sign-Post” Role of Brain Glycoproteins in Cell Recognition, Its Change in Brain Tumor, and the Presence of a ‘Distance Factor’. In Proteins of the Nervous System. I. Morgan, Ed. Plenum Press, in press.Google Scholar
  25. 25.
    BOGOCH, S. and KORSH, G. Methods for Hydrolysis of Glycoproteins, Ion-exchange Column Chromatography and Thin-layer Chromotography of Constituent Hexose and Hexosamines. to be publishedGoogle Scholar
  26. 26.
    ESSER, K., J. Chromatog., 18, 414, 1965.CrossRefGoogle Scholar
  27. 27.
    GUNTER, H., and SCHWEIGER, A. J. Chromatog., 17, 602, 1965.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • Samuel Bogoch
    • 1
  1. 1.Foundation for Research on the Nervous System and Dreyfus Medical FoundationBoston University School of MedicineUSA

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