Fine Structure of Early Tay-Sachs Disease

  • M. Adachi
  • J. Torii
  • L. Schneck
  • B. W. Volk
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 19)

Abstract

Tay-Sachs disease is an inborn error of glycolipid. It is characterized by massive accumulation of GM2-ganglioside (4), mainly in the brain and by the absence of the enzyme hexosaminidase A (5). Despite the significant increase of our knowledge of the biochemical aspects of this disorder during the past few years, the ultrastructural alterations of the neuronal organelles related to the accumulation and the evolution of the intracytoplasmic deposited lipid material at the early stage of Tay-Sachs disease are unknown.

Keywords

Kupffer Cell Luxol Fast Blue Marked Dilatation Axonal Fiber Cerebral Neuron 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1972

Authors and Affiliations

  • M. Adachi
    • 1
  • J. Torii
    • 1
  • L. Schneck
    • 1
  • B. W. Volk
    • 1
  1. 1.Isaac Albert Research Institute of the Kingsbrook Jewish Medical CenterBrooklynUSA

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