Ferro-Carbon Particles

Preparation and Clinical Applications
  • Anatoly A. Kuznetsov
  • Avetik R. Harutyunyan
  • Edward K. Dobrinsky
  • Victor I. Filippov
  • Andrei G. Malenkov
  • Anatoly F. Vanin
  • Oleg A. Kuznetsov
Chapter

Abstract

A variety of magnetic adsorbents for different biomedical applications have been developed. The adsorbents are fine disperse particles, consisting of a ferromagnetic core made of iron or its oxides, and attached to a carbon structure or coated with carbon. The size of the particles is 0.01 to 1 µm. The carbon phase is porous, has a considerable specific surface and is a good adsorbent. It can be manufactured with selective sorption properties. The ferromagnetic core allows the use of a magnetic field to guide and move the particles and regulate their agglomeration behavior. The particles were produced by three different methods, and their sorption properties, shape, size distribution, magnetic and biological properties were studied. The particles were successfully used in several biomedical applications, including magnetic localization of anti-cancer drugs in the tumor zone. Magnetic targeting allows to create a hundred times higher concentrations of anti-cancer antibiotics in the tumor compared with other organs, which is maintained for 8 to 10 days after a single injection. Animal and pre-clinical trials have been completed and permission for clinical trials on cancer patients with high grade disease was obtained. Since 1990, more than a hundred patients with different types of tumors have been treated in several Russian clinics. Many patients had either full recovery or their condition was considerably improved.

Keywords

Iron Particle Weak Magnetic Field Iron Carbonyl Adsorbent Particle Magnetic Localization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Anatoly A. Kuznetsov
    • 1
  • Avetik R. Harutyunyan
    • 2
  • Edward K. Dobrinsky
    • 2
  • Victor I. Filippov
    • 2
  • Andrei G. Malenkov
    • 2
  • Anatoly F. Vanin
    • 2
  • Oleg A. Kuznetsov
    • 2
  1. 1.Synmatix CorporationSouthfieldUSA
  2. 2.Institute of Biochemical PhysicsRussian Academy of SciencesMoscowRussia

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