Site-Specific Cleavage of Insulin-Like Growth Factor II mRNAs

  • Erwin L. van Dijk
  • P. Elly Holthuizen
Part of the Endocrine Updates book series (ENDO, volume 16)

Abstract

Insulin-like growth factor II (IGF-II) is a protein involved in growth and differentiation of numerous cell types. Because of the importance of IGF-II in many different processes, various regulatory mechanisms are available in the cell to control IGF-II protein synthesis, reflecting the vital importance of fine tuning and rapid regulation of IGF-II mRNA levels and IGF-II protein amount. One such mechanism is the site-specific endonucleolytic cleavage of IGF-II mRNAs, which will be described in this chapter. The role of an RNA-binding protein that is associated with the highly structured RNA will be discussed as well as the requirements for recognition of the IGF-II mRNA by an endoribonuclease.

Keywords

Cleavage Site Cleavage Product Chicken Embryo Fibroblast Homeostatic Regulation Cleavage Efficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Erwin L. van Dijk
    • 1
  • P. Elly Holthuizen
    • 2
  1. 1.Centre de Genetique MoleculaireGif-sue-Yvette, CedexFrance
  2. 2.University Medical Center UtrechtUtrechtThe Netherlands

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