Intraspecies Extrapolation: Efforts at Enhancing Dose-Response Relationships
I think that it is safe to say that the process of assessing the human health risk posed by exposure to toxic chemicals is far more often based on animal toxicity data than on human data. That being the case, those who perform such risk assessments (myself included) are often faced with the need to extrapolate from animal data to estimates of human risk. This requirement for intraspecies extrapolation has been around a long time and is the practical basis for toxicology; unfortunately, it is fraught with uncertainty because of the large number of assumptions normally required due most frequently to insufficient information.
KeywordsStratum Corneum Benzyl Alcohol Human Health Risk Assessment Respiratory Minute Volume Vinyl Bromide
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- Anderson ME. 1980. Saturable metabolism and its relationship to toxicity. Wright-Patterson AFB, OH: Air Force Aerospace Medical Research Laboratory, AFAMRL-TR-80–18.Google Scholar
- Andersen ME. 1981. A physiologically-based toxicokinetic description of the metabolism of inhaled gases and vapors: analysis at steady-state. Wright-Patterson AFB, OH: Air Force Aerospace Medical Research Laboratory, AFAMRL-TR-81–8.Google Scholar
- Andersen ME, Gargas ML, Jones RA, Jenkins LJ. 1980. Determination of the kinetic constants for metabolism of inhaled toxicants in vivo using gas uptake measurements. Toxicol. Appl. Pharmacol. 54: 100–116.Google Scholar
- Anderson MW, Hoel DG, Kaplan NL. 1980. A general scheme for the incorporation of pharmacokinetics in low-dose risk estimation for chemical carcinogenesis: example - vinyl chloride. Toxicol. Appl. Pharmacol. 55: 154–161.Google Scholar
- Gehring PJ, Watanabe PG, Park CN. 1978. Resolution of dose-response toxicity data for chemicals requiring metabolic activation: example - vinyl chloride. Toxicol. Appl. Pharmacol. 44: 581–591.Google Scholar
- ICRP (International Commission on Radiological Protection). 1975. Physiological data for reference man. In: Report of the task groupGoogle Scholar
- on reference man, no. 23. New York: Pergamon Press, pp. 335–365.Google Scholar
- Leong KJ, Dowd GF, MacFarland HN. 1964. A new technique for tidal volume measurement in unanaesthetized small animals. Can. J. Physiol. Pharmacol. 42: 189–198.Google Scholar
- Menzel DB, McClellan RO. 1980. Toxic responses of the respiratory system. In: Doull J. Klaassen CD, Amdur MO, eds. Casarett and Doull’s toxicology. The basic science of poisons, 2nd edition. New York: Macmillan Publishing Co., Inc., pp. 246–274.Google Scholar
- Roberts MS, Anderson RA, Moore DE, Swarbrick J. 1977. The distribution of non-electrolytes between human stratum corneum and water. Aust. J. Pharm. ci. 6 (3): 77–82.Google Scholar
- Scheuplein RJ. 1965. Mechanism of percutaneous adsorption I. Routes of penetration and the influence of solubility. J. Invest. Dermatol. 45(5)334–346.Google Scholar
- Shell Development Company. 1980. Product literature. 1,4-dioxane in alcohol ethoxysulfate products. Houston: Shell Development Company. Ter Haar G, Ethyl Corporation, Baton Rouge, LA 70801. April 16, 1979b. Submission to Docket Officer, OSHA on the histopathology of vinyl bromide.Google Scholar