Abstract

Chemical sensing is part of an information acquisition process in which some insight is obtained about the chemical composition of the system in real time. In this process an amplified electric signal results from the presence of some chemical species. Generally, it consists of two distinct steps: recognition and amplification. An example is the ordinary measurement of pH with a glass electrode (Figure 1-1). The interaction of the hydronium ion with the electrode is highly specific, but the power in the primary electric signal is very low. For a 10 MΩ glass electrode and 1 mV error it would be approximately 1 pW. If we try to draw more power from such an electrode, the information would be distorted or destroyed. In other words, the source of the signal (electrode) requires an amplifier (pH meter) in order to obtain the information in a useful, undistorted form. Thus the recognition (selectivity) is provided by some chemical interaction while the amplification can be provided by some physical means. There are exceptions, however, to this statement: for example, enzymatic reactions combine the high selectivity of the enzyme binding for a given substrate with catalytic properties of the enzyme that represent an amplification step in its own right.

Keywords

Binding Constant General Aspect Chemical Sensor Flow Injection Analysis Selectivity Coefficient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References for Chapter 1

  1. 1.
    K. E. van Holde, Physical Biochemistry, 2nd ed., Prentice-Hall, New York, 1985.Google Scholar
  2. 2.
    H. Stieve, Sensors and Actuators 4 (1983) 689.CrossRefGoogle Scholar
  3. 3.
    D. R. Absolom and C. J. van Oss, CRC Crit. Rev. Immunol. 6 (1986) 1.Google Scholar
  4. 4.
    M. A. Sharaf, D. L. Illman, and B. Kowalski, Chemometrics, Wiley, New York, 1986.Google Scholar
  5. 5.
    S. D. Caras, J. Janata, D. Saupe, and K. Schmidt, Anal. Chem. 57 (1985) 1917.CrossRefGoogle Scholar
  6. 6.
    L. E. Hood, I. L. Weissman, W. B. Wood, and J. H. Wilson, Immunology, 2nd ed., Benjamin & Cummings, Menlo Park, 1984.Google Scholar
  7. 7.
    B. L. Liu and J. S. Schultz, IEEE Trans. Biomed. Eng. BME-33 (1986) 133.Google Scholar
  8. 8.
    Various authors, Immobilization of proteins, in: Methods in Enzymology (K. Mosbach and B. Danielsson, eds.), Vols. 135 and 136, Academic Press, Orlando, Florida, 1987.Google Scholar
  9. 9.
    M. A. Arnold, Ion-Sel. Electrode Rev. 8 (1986) 85.Google Scholar
  10. 10.
    S. D. Caras, D. Petelenz, and J. Janata, Anal. Chem. 57 (1985) 1920.CrossRefGoogle Scholar
  11. 11.
    Y. Hanazato, M. Nakako, M. Maeda, and S. Shiono, Anal. Chim. Acta 193 (1987) 87.CrossRefGoogle Scholar
  12. 12.
    Y. Miyahara, T. Moriizumi, and K. Ichimura, Sensors and Actuators 7 (1985) 1.CrossRefGoogle Scholar
  13. 13.
    S. J. Pace, Sensors and Actuators 1 (1981) 499.CrossRefGoogle Scholar
  14. 14.
    J. Ruzicka and E. H. Hansen, Flow Injection Analysis, Wiley, New York, 1988.Google Scholar
  15. 15.
    K. Stulik and V. Pacakova, Electroanalytical Measurements in Flowing Liquids, Wiley, New York, 1987.Google Scholar
  16. 16.
    A. J. Bard and L. Faulkner, Electrochemical Methods, Wiley, New York, 1980.Google Scholar
  17. 17.
    K. Matsumoto, H. Seijo, T. Watanabe, I. Karube, I. Satoh, and S. Suzuki, Anal. Chim. Acta 105 (1979) 429.CrossRefGoogle Scholar
  18. 18.
    I. Karube and M. Suzuki, Biosensors 2 (1986) 343.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Jiří Janata
    • 1
  1. 1.University of UtahSalt Lake CityUSA

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