Changes in brain monoaminergic systems in apomorphine-sensitized aggressive male Wistar rats

  • Lembit Allikmets
  • Vallo Matto
Chapter

Abstract

Apomorphine, an unselective dopamine Dl and D2 receptor agonist, induces in laboratory animals (mice and rats), several behavioural phenomena such as stereotyped behaviour, hyperlocomotion, aggressiveness, etc 1–3. The apomorphine-induced (0.5–1.0 mg/kg, once or twice daily during 10–15 days) aggression has been considered to be an animal model of human psychotic behaviour4,5. This hypothesis is evidenced by the fact that most of the psychotropic drugs used in clinical practice for the treatment of psychosis attenuate or completely block the apomorphine-induced aggression in adult male Wistar rats. Though the mechanisms of action of those drugs are known, the neurobiology of the apomorphine-induced aggression is not well understood6.

Keywords

High Pressure Liquid Chromatography Monobasic Sodium Phosphate Aggressive Posture Octanesulfonic Acid Neurochemical Analysis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Allikmets, L.H., Stanley, M., and Gershon, S., 1979, The effect of lithium on chronic haloperidol enhanced apomorphine aggression in rats. Life Sci. 25: 165–170.PubMedCrossRefGoogle Scholar
  2. 2.
    Battisti, J.J., Uretsky, N.J., and Wallace, L.J., 1999, Sensitization of apomorphine-induced stereotyped behaviour in mice is context dependent. Psychopharmacology 146: 42–48.PubMedCrossRefGoogle Scholar
  3. 3.
    Kostowski, W., Valzelli, L., and Baiguerra, G., 1986, Effect of chronic administration of alprazolam and adinazolam on clonidine-or apomorphine-induced aggression in laboratory rodents. Neuropharmacology 25: 757–761.PubMedCrossRefGoogle Scholar
  4. 4.
    Lang, A., Harro, J., Soosaar, A., Kóks, S., Volke, V., Oreland, L., Bourin, M., Vasar, V., Bradwejn, J., and Mlinnistó, P., 1995, Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats. NaunynSchmiedeberg’s Arch PharmacoL 351: 363–370.Google Scholar
  5. 5.
    Lang, A., Soosaar, A., Kóks, S., Volke, V., Bourin, M., Bradwejn, J., and Vasar, V., 1994, Pharmacological comparison of antipsychotic drugs and sigma antagonists in rodents. Pharmacol. Toxicol. 75: 222–227.PubMedCrossRefGoogle Scholar
  6. 6.
    Matto, V., Allikmets, L, and Skrebuhhova, T., 1998, Apomorphine—induced aggressiveness and [3Hlcitalopram binding after antidepressant treatment in rats. Pharmacol. Biochem. Behay. 59: 747–752.CrossRefGoogle Scholar
  7. 7.
    Rudissaar, R, Pruus, K., Skrebuhhova, T., Allikmets, L, and Matto, V.. Modulatory role of 5-HT3 receptors in the mediation of apomorphine-induced aggressive behaviour in male rats. Behay. Brain Res. 106: 91–96.Google Scholar
  8. 8.
    Matto, V., Vaarmann, A., Rudissaar, R., Pruus, K., Skrebuhhova-Malmros, T., and Allikmets, L., 2000, Apomorphine-induced aggressive behaviour and post-mortem monoamine content in male Wistar rats. Neurosci. Leu. 289: 131–134.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Lembit Allikmets
    • 1
  • Vallo Matto
    • 1
  1. 1.Department of PharmacologyUniversity of TartuTartuEstonia

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