Models of Connective Tissue Disease

  • Jerry C. Jacobs
Chapter
Part of the Comprehensive Manuals in Pediatrics book series (CM PEDIATRICS)

Abstract

The pathogenesis of rheumatic diseases remains an enigma. Errors of immunologic regulatory mechanisms seem to be involved.1 However, even when an inducer of disease, such as the Streptococcus in acute rheumatic fever or Shigella, Salmonella, or Yersinia in spondyloarthritis, has finally been identified, the effector or suppressor mechanisms that lead to or prevent the subsequent development of the disease or which cause it to remit remain obscure. Genetic, infectious, and immunologic factors can usually all be implicated. The relationships between these various influences on the pathogenesis of a disease are extremely complex. Animals provide useful models for studying these interactions (Table 9.1).

Keywords

Kawasaki Disease Connective Tissue Disease Adjuvant Arthritis Acute Rheumatic Fever Equine Viral Arteritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. 1.
    Janossy G, Duke O, Poulter LW, et al.: Rheumatoid arthritis: A disease of T-lymphocyte/macrophage immunoregulation. Lancet 2: 839–842, 1981.PubMedCrossRefGoogle Scholar
  2. 2.
    Chess L: Cellular immunology. In: Cohen AS (ed.) The Science and Practice of Clinical Medicine, vol. 4. Grune and Stratton, New York, 1979, pp. 378–388.Google Scholar
  3. 3.
    Geha RS: Current concepts in immunology: Regulation of the immune response by idiotypic-antiidiotypic interactions. N Engl J Med 305: 25–28, 1981.PubMedCrossRefGoogle Scholar
  4. 4.
    Gershon RK: Clonal selection and after, and after. (Editorial) N Engl J Med 300: 1105–1107, 1979.PubMedGoogle Scholar
  5. 5.
    Norton WL: Aleutian mink and New Zealand mice models of viral induced connective tissue disease. Rheumatology (Basel) 3:194–223, 1970; The Immunochemistry and Biochemistry of Connective Tissue and its Disease States. Karger, Basel, München, New York.Google Scholar
  6. 6.
    Milich DR, Gershwin ME: The pathogenesis of autoimmunity in New Zealand mice. Semin Arthritis Rheum 10: 111–147, 1980.PubMedCrossRefGoogle Scholar
  7. 7.
    Whaley K, Hughes GRV, Webb J: Systemic lupus erythematosus in man and animals. In: Buchanan WW, Dick WC (eds.) Recent Advances in Rheumatology, vol. 1. Churchill Livingstone, New York, 1976, pp. 67–136.Google Scholar
  8. 8.
    Talal N: Disordered immunologic regulation and autoimmunity. Trans Rev 31: 240263, 1976.Google Scholar
  9. 9.
    Steinberg AD, Reinertsen JL: Lupus in New Zealand mice and in dogs. Bull Rheum Dis 28: 940–947, 1978.Google Scholar
  10. 10.
    Henson JB, Crawford TB: The pathogenesis of virus-induced arterial disease-Aleutian disease and equine viral arteritis. Adv Cardiol 13: 183–191, 1974.PubMedGoogle Scholar
  11. 11.
    Mikkelsen WM (ed.): Twenty-third rheumatism review. Arthritis Rheum 21 (Suppl. 8): R177–R196, 1978.Google Scholar
  12. 12.
    Walker SE, Schnitzer B: Resistance to therapy in mature Palmerston North mice treated with cyclophosphamide or hydrocortisone sodium succinate. Arthritis Rheum 23: 539–544, 1980.PubMedCrossRefGoogle Scholar
  13. 13.
    Pearson CM: Arthritis in animals. In: McCarty DU (ed.) Arthritis and Allied Conditions, 9th ed. Lea and Febiger, Philadelphia, 1979, pp. 308–319.Google Scholar
  14. 14.
    Chronic arthritis of rabbits induced by mycoplasmas. I. Clinical, microbiologic and histologic features. Arthritis Rheum 23: 825–845, 1980.CrossRefGoogle Scholar
  15. 15.
    Stuart JM, Cremer MA, Kang AH, et al.: Collagen-induced arthritis in rats: Evaluation of early immunologic events. Arthritis Rheum 22: 1344–1351, 1979.PubMedCrossRefGoogle Scholar
  16. 16.
    Chang Y, Pearson CM, Abe C: Adjuvant polyarthritis. IV. Induction by a synthetic adjuvant: Immunologic, histopathologic and other studies. Arthritis Rheum 23: 6271, 1980.CrossRefGoogle Scholar
  17. 17.
    Morgan G, Peter JV, Newbould BB: Experimental allergic myositis in rats. Arthritis Rheum 14: 599–609, 1971.PubMedCrossRefGoogle Scholar
  18. 18.
    Statsny P, Stembridge VA, Ziff M: Homologous disease, a model for human autoimmune disease. Arthritis Rheum 6: 64–69, 1963.CrossRefGoogle Scholar
  19. 19.
    Brinckerhoff CE, McMillan RM, Dayer JM, et al.: Inhibition by retinoic acid of collagenase production in rheumatoid synovial cells. N Engl J Med 303: 432–436, 1980.PubMedCrossRefGoogle Scholar
  20. 20.
    Steinberg J, Tsukamoto S, Sledge CB: A tissue culture model of cartilage breakdown in rheumatoid arthritis. III. Effects of antirheumatic drugs. Arthritis Rheum 22: 877885, 1979.Google Scholar
  21. 21.
    Schwartz ER, Greenwald RA: Experimental models of osteoarthritis. Bull Rheum Dis 30: 1030–1033, 1980.Google Scholar
  22. 22.
    Palmoski MJ, Colyer RA, Brandt KD: Joint motion in the absence of normal loading does not maintain normal articular cartilage. Arthritis Rheum 23: 325–334, 1980.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1982

Authors and Affiliations

  • Jerry C. Jacobs
    • 1
  1. 1.Section of Pediatric Rheumatology Department of Pediatrics College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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