Microcirculation Assessment in Vasculopathies

Capillaroscopy and Peripheral Tissue Oxygenation
  • G. Cicco
  • G. Placanica
  • V. Memeo
  • P. M. Lugarà
  • L. Nitti
  • G. Migliau
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 540)

Abstract

In the study of peripheral occlusive disease (e.g. progressive ischaemic syndrome), many parameters have been investigated using different methods and techniques: including hemorheology, microcirculatory blood flow, tissue oxygenation, microvasculature red blood cell (RBC) perfusion, and RBC deformability and aggregability in vitro with the laser assisted optical rotational red blood cells analyzer (LORCA)1−3. In addition, to explain some biochemical aspects we detected the intra-RBC cytosolic calcium (Ca++) level4,5. The oxygen carrying capacity of microcirculatory blood has also been studied, as transcutaneous oxygen partial pressure (TcpO2)6, oxyhemoglobin saturation percentage (% sat HbO2) using standard instruments and our prototype Oxyraf7,8, as well as total oxygen concentration9. We were particularly interested in the microcirculation in peripheral occlusive arterial disease (POAD) focusing on in vivo studies with capillaroscopy of morphology in relation to assessment of tissue oxygenation. Therefore, in the present study we investigated whether these two methodologies could be combined to evaluate microvasculature capillaries, especially in arterial vasculopathy, to define microvasculature perfusion.

Keywords

Loop Number Tissue Oxygenation Capillary Number Peripheral Occlusive Arterial Disease Abstract Book 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • G. Cicco
    • 1
  • G. Placanica
    • 4
  • V. Memeo
    • 1
    • 2
  • P. M. Lugarà
    • 1
    • 2
    • 3
  • L. Nitti
    • 1
    • 2
  • G. Migliau
    • 4
  1. 1.Centro Interdipartimentale di Ricerche in Emoreologia, Microcircolazione, Trasporto di Ossigeno e Tecnologie Ottiche non InvasiveUniversità di BariItaly
  2. 2.Dip. D.E.T.O. — Dip. dell’Emergenza e dei Trapianti di OrganiUniversità di BariItaly
  3. 3.Dip. Interateneo di FisicaUnità INFMBariItaly
  4. 4.Dip. Medicina Clinica — Cattedra di CardiologiaUniversità “La Sapienza”RomaItaly

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