Age-Related Alteration of Brain Function during Cerebral Ischemia
A great deal of knowledge has been accumulated during the last decade concerning the aging brain in health and disease. One of the major diseases causing death and disability in the elderly is ischemic stroke. However, in vivo studies, including the evaluation of brain function under ischemic conditions, have relied on models of focal cerebral ischemia in young brains. It is well documented that even in normal aging, the functional metabolism of the brain and its blood supply inevitably decline.
KeywordsCarotid Artery Aging Brain Carotid Artery Occlusion Extracellular Potassium Spontaneous Electrical Activity
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- 1.T. Bar Morphometric evaluation of capillaries in different laminae of rat cerebral cortex by automatic image analysis: changes during development and aging, Adv. Neurol. 20, 1–9 (1978)Google Scholar
- 3.H. A. Wolinsky Long term effects of hypertension in the rat aortic wall and their relation to cocurrent aging changes: morphological and chemical studies, Circ. Res. 30, 301–309 (1972)Google Scholar
- 4.J. Marnn Age-related changes in vascular responses: a review, Mech. Ageing Dev. 79, 71–114 (1995)Google Scholar
- 7.J. C. de la Tone Cerebromicrovascular pathology in Alzheimer’s disease compared to normal aging, Gerontology 43, 26–43 (1997)Google Scholar
- 11.A. Mayevsky Biochemical and physiological activities of the brain as in vivo markers of brain pathology. in: Bernstein, E. F., Callow, A. D., Nicolaides, A. N., and Shifrin, E. G. eds. Cerebral, Revascularization. Med-Orion Pub. 1993, 51–69.Google Scholar
- 12.S. Meilin, N. Zarchin, A. Mayevsky, and S. Shapira Multiparametric responses to cortical spreading depression under nitric oxide synthesis inhibition. in: Weissman, B. A., Alon, N., and Shapira, S. eds. Biochemical Pharmacological and Clinical Aspects of Nitric Oxide. New York, Plenum Press. 1995, 195–204.CrossRefGoogle Scholar
- 13.S. Meilin, G. G. Rogatsky, S. R. Thom, N. Zarchin, E. Guggenheimer-Furman, and A. Mayevsky Effects of carbon monoxide exposure on the brain may be mediated by nitric oxide, J. Appl. Physiol. 81, 10781083 (1996)Google Scholar
- 16.M. Osbakken, A. Mayevsky, I. Ponomarenko, D. Zhang, C. Duska, and B. Chance Combined in vivo NADH fluorescence and 31P-NMR to evaluate myocardial oxidative phosphorylation, J. Appl. Cardiol. 4, 305–313 (1989)Google Scholar