Phosphorus and the Ferritin Iron Core: Function-Balanced Biomineralization

  • Kenneth M. Towe

Abstract

In the biomineralization of storage iron, the proteins ferritin and hemosiderin sequester iron in a mineral form of colloidal dimensions ( <80 Å). This mineral is the metastable hydrous ferric oxide ferrihydrite (5Fe2O3·9H2O). Ferrihydrite represents an appropriate mineralogical choice to balance the important but opposing physiological functions of iron storage; and iron mobility. The ferrihydrite in both ferritin and hemosiderin contains important amounts of non-structural phosphorus adsorbed to the crystallite surfaces. Experimental data support the suggestion that this phosphorus can act to preserve the role of iron mobility by inhibiting the potential during iron storage for inversion of the more readily soluble, metastable ferrihydrite to one of the less soluble, more stable phases such as goethite (αFeOOH) or hematite (αFe2O3).

Keywords

Differential Thermal Analysis Iron Storage Ferric Oxide Iron Core Ferric Hydroxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. BANYARD, S.H., STAMMERS, D.K., and HARRISON, P.M., 1978. Electron density map of apoferritin at 2.8 A resolution. Nature, London, 271, 282–284.CrossRefGoogle Scholar
  2. CHUKROV, F.V., ZVYAGIN, B.B., GORSCHKOV, A, YERMILOVA, L.P., and RUDNITSKAYA, E.S., 1971. The Towe-Bradley phase - a product of the supergene alteration of ores. Izvestiya Akademii Nauk SSSR, seriya geologicheskaya, no. 1.Google Scholar
  3. CHUKROV, F.V., ZVYAGIN, B.B., GORSCHKOV, A, YERMILOVA, L.P., and BALASHOVA, V.V., 1973. Oferrigidrite. Izvestiya Akademii Nauk SSSR, seriya geologicheskaya, no. 4, 23–33.Google Scholar
  4. CHUKROV, F.V., ZVYAGIN, B.B., GORSCHKOV, A, YERMILOVA, L.P., and BALASHOVA, V.V., 1973. English translation: Ferrihydrite. International Geology Review, 16, 1131–1143.CrossRefGoogle Scholar
  5. FISCHBACH, F.A., GREGORY, D.W., HARRISON, P.M., IIOY, T.G., and WILLIAMS, J.M., 1971. On the structure of hemosiderin and its relationship to ferritin. Journal of Ultrastructure Research, 37, 495–503.PubMedCrossRefGoogle Scholar
  6. FORD, G.C., HARRISON, P.M., RICE, D.W., SMITH, J.M.A., TREFFRY, A., WHITE, J.L., and YARIV, J., 1984. Ferritin: design and formation of an iron-storage molecule. Philosophical Transactions Royal Society of London, B304, 551–565.CrossRefGoogle Scholar
  7. GRANICK, S., 1942. Ferritin. I. Physiological and chemical properties of horse spleen ferritin. Journal of Biological Chemistry, 146, 451–461.Google Scholar
  8. HAGGIS, G.H., 1965. The iron oxide core of the ferritin molecule. Journal of Molecular Biology, 14, 598–602.PubMedCrossRefGoogle Scholar
  9. HARRISON, P.M., 1969. The biochemistry of iron. In Iron Metabolism and Anemia, Pan American Health Organization, Scientific Publication No. 184, 2–20.Google Scholar
  10. HARRISON, P.M. and I IOY, T.G., 1973. Ferritin. In Inorganic Biochemistry, vol. 1 (ed. G.L. Eichhorn ), pp. 253–279. Amsterdam: Elsevier.Google Scholar
  11. HARRISON, P.M., FISCHBACH, F.A., IIOY, T.G., and HAGGIS, G.H., 1967. Ferric oxyhydroxide core of ferritin. Nature, London, 216, 1188–1190.CrossRefGoogle Scholar
  12. JACKSON, T.A. and KELLER, W.D., 1970. Evidence for biogenic synthesis of an unusual ferric oxide mineral during alteration of basalt by a tropical lichen. Nature, London, 227, 522–523.CrossRefGoogle Scholar
  13. LANGMUIR, D., 1969. The Gibbs free energies of substances in the system Fe-02-H2O-CO2 at 25°C. U.S. Geological Survey Professional Paper 650-B, B180–B184.Google Scholar
  14. LANGMUIR, D., 1971. Particle size effect on the reaction goethite = hematite + water. American Journal of Science, 271, 147–156.CrossRefGoogle Scholar
  15. MACKENZIE, R.C., 1952. Investigations on cold-precipitated hydrated ferric oxide and its origin in clays. In Problems of Clay and Laterite Genesis, pp. 65–75, New York: American Institute of Mining Engineers.Google Scholar
  16. MANSOURI, A.N., THOMPSON, C., TIIEIL, E.C., CHASTEEN, N.D., and SAYERS, D.E., 1985. Fe(III) ATP complexes: models for ferritin and other polynuclear iron complexes with phosphate. Journal of Biological Chemistry, 260, 7975–7979.Google Scholar
  17. MASSOVER, W.H. and COWLEY, J.M., 1973. The ultrastructure of ferritin macromolecules. The lattice structure of the core crystallites. Proceedings of the National Academy of Sciences, U.S.A., 70, 3847–3851.CrossRefGoogle Scholar
  18. SCHWERTMANN, U. and FISCHER, W.R., 1973. Natural “amorphous” ferric hydroxide. Geoderma, 10, 237–247.CrossRefGoogle Scholar
  19. TOWE, KM., 1981. Structural distinction between ferritin and iron dextran (Imferon). Journal of Biological Chemistry, 256, 9377–9378.PubMedGoogle Scholar
  20. TOWE, KM. and BRADLEY, W.H., 1967. Mineralogical constitution of colloidal “hydrous ferric oxides”. Journal of Colloid and Interface Science, 24, 384–392.CrossRefGoogle Scholar
  21. TOWE, KM. and LOWENSTAM, H.A., 1967. Ultrastructure and development of iron mineralization in the radular teeth of Cryptochiton stellen ( Mollusca ). Journal of Ultrastructure Research, 17, 1–13.PubMedCrossRefGoogle Scholar
  22. TREFFRY,A. and HARRISON, P.M., 1978. Incorporation and release of inorganic phosphate in horse spleen ferritin. Biochemical Journal, 171, 313–320.Google Scholar
  23. VAN DER GIESSEN, A.A., 1966. The structure of iron(III) oxide-hydrate gels. Journal of Inorganic and Nuclear Chemistry, 28, 2155–2159.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Kenneth M. Towe
    • 1
  1. 1.Department of PaleobiologySmithsonian InstitutionUSA

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