INR — Calibration of the Therapeutic Range

  • Leon Poller

Abstract

The prothrombin time (PT) is the most important coagulation test. After many years of disagreement, an international system of standardisation has been accepted. Fifty years after Quick1 described the PT to detect coagulation defects, the control of oral anticoagulant therapy is still largely dependent on the test. Many modifications to the original technique have been introduced, and new methods have been developed specifically, e.g. the prothrombin and proconvertin test (P and P test),2 and the Throm-botest,3 but their application has been limited in comparison. Clinical reports of anticoagulant trials, giving no details of the PT method are still published.(e,g.4)

Keywords

Deep Vein Thrombosis International Normalise Ratio Therapeutic Range Oral Anticoagulant Oral Anticoagulant Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Leon Poller
    • 1
  1. 1.UK Reference Laboratory for Anticoagulant Reagents & ControlWithington HospitalManchesterUK

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