In Vitro Production of Marine-Derived Antitumor Compounds

  • Shirley A. Pomponi
  • Robin Willoughby
  • Amy E. Wright
  • Claudia Pecorella
  • Susan H. Sennett
  • Jose Lopez
  • Gail Samples
Chapter

Abstract

The sustainable supply of marine-derived bioactive compounds to meet demands for pre-clinical and clinical evaluation is a major consideration in drug development strategies. It is also a concern to environmental resource managers, particularly since conservation of genetic resources may preclude harvesting as a bulk supply strategy. Our research addresses this need by focusing on in vitro production of antitumor compounds through cell culture of the source organisms. Our objectives are: to establish cultures of bioactive marine invertebrates that can be used as models to study in vitro production of antitumor compounds and the factors which control expression of their production; to provide bulk supplies of these compounds through in vitro production; and to produce new structural analogs via manipulation of culture conditions.

Keywords

Bioactive Metabolite Bovine Pituitary Extract Sponge Cell Microwell Plate Antitumor Compound 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Shirley A. Pomponi
    • 1
  • Robin Willoughby
    • 1
  • Amy E. Wright
    • 1
  • Claudia Pecorella
    • 1
  • Susan H. Sennett
    • 1
  • Jose Lopez
    • 1
  • Gail Samples
    • 1
  1. 1.Harbor Branch Oceanographic Institution, Inc.Fort PierceUSA

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