Human T Cell Receptor γδ Structure

  • Michael B. Brenner
  • Frans Hochstenbach
  • Hamid Band
  • Christina Parker
  • Joanne McLean
  • Shingo Hata
  • Michael Krangel

Abstract

A subpopulation of peripheral blood T-lymphocytes exists that is distinct from T cells that express the T cell receptor (TCR) αβ. This population of T cells expresses a receptor composed of TCR γ and TCR δ polypeptides that are associated with CD3 (Brenner et al., 1986). The TCR γ gene (Saito et al., 1984; Quertermous et al., 1986) has been extensively examined and is composed of variable (V), joining (J), and constant (C) region gene segments that undergo somatic rearrangement during development (Hayday et al., 1985).

Keywords

Cell Receptor Dana Farber Cancer Institute Cell Receptor Gene Somatic Rearrangement Complete Primary Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Michael B. Brenner
    • 1
    • 2
  • Frans Hochstenbach
    • 1
  • Hamid Band
    • 1
  • Christina Parker
    • 1
  • Joanne McLean
    • 1
  • Shingo Hata
    • 3
  • Michael Krangel
    • 3
  1. 1.Laboratory of Immunochemistry, Dana Farber Cancer InstituteHarvard Medical SchoolBostonUSA
  2. 2.Department of Rheumatology and Immunology, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  3. 3.Division of Tumor Virology, Dana Farber Cancer InstituteHarvard Medical SchoolBostonUSA

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