Human T Cell Receptor γδ Structure

  • Michael B. Brenner
  • Frans Hochstenbach
  • Hamid Band
  • Christina Parker
  • Joanne McLean
  • Shingo Hata
  • Michael Krangel
Chapter

Abstract

A subpopulation of peripheral blood T-lymphocytes exists that is distinct from T cells that express the T cell receptor (TCR) αβ. This population of T cells expresses a receptor composed of TCR γ and TCR δ polypeptides that are associated with CD3 (Brenner et al., 1986). The TCR γ gene (Saito et al., 1984; Quertermous et al., 1986) has been extensively examined and is composed of variable (V), joining (J), and constant (C) region gene segments that undergo somatic rearrangement during development (Hayday et al., 1985).

Keywords

Cell Receptor Dana Farber Cancer Institute Cell Receptor Gene Somatic Rearrangement Complete Primary Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Brenner, M.B., McLean, J., Dialynas, D.P., Strominger, J.L., Smith, J.A., Owen, F.L., Seidman, J.G., Ip, S., Rosen, F., and Krangel, M.S. Identification of a putative second T-cell receptor. Nature 322: 145–149 (1986).PubMedCrossRefGoogle Scholar
  2. 2.
    Brenner, M.B., McLean, J., Scheft, H., Riberdy, J., Ang, S.-L., Seidman, J.G., Devlin, P., and Krangel, M.S. Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes. Nature 325: 689–694 (1987).PubMedCrossRefGoogle Scholar
  3. 3.
    Chien, Y., Iwashima, M., Kaplan, K.B., Elliott, J.F., and Davis, M.M. A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation. Nature 327: 677–682 (1987).PubMedCrossRefGoogle Scholar
  4. 4.
    Chien, Y-h., Iwashima, M., Wettstein, D.A., Kaplan, K.B., Elliot, J.F., Born, W., Davis, M.M. T-cell receptor S gene rearrangements in early thymocytes. Nature 330: 722–727 (1987).PubMedCrossRefGoogle Scholar
  5. 5.
    Hata, S., Brenner, M.B., and Krangel, M.S. Identification of putative human T cell receptor S complementary DNA clones. Science 238: 678–682 (1987).PubMedCrossRefGoogle Scholar
  6. 6.
    Hata, S., Satyanarayana, K., Devlin, P., Band, H., McLean, J., Strominger, J.L., Brenner, M.B., Krangel, M.S. Extensive junctional diversity of rearranged human T cell receptor S genes. Science 240: 1541–1544 (1988).PubMedCrossRefGoogle Scholar
  7. 7.
    Hayday, A.C., Saito, H., Gillies, S.D., Kranz, D.M., Tanigawa, G., Eisen, H.N., and Tonegawa, S. Structure, organization, and somatic rearrangement of T cell gamma genes. Cell 40: 259–269 (1985).PubMedCrossRefGoogle Scholar
  8. 8.
    Hochstenbach, F., Parker, C., McLean, J., Gieselmann, V., Band, H., Bank, I., Chess, L., Spits, H., Strominger, J.L., Seidman, J.G., Brenner, M.B. Characterization of a third form of the human T-cell receptor yS. J Exp Med 168: 761–776 (1988).PubMedCrossRefGoogle Scholar
  9. 9.
    Krangel, M.S., Band, H., Hata, S., McLean, J., and Brenner, M.B. Structurally divergent human T cell receptor g proteins encoded by distinct Cy genes. Science 237: 64–67 (1987).PubMedCrossRefGoogle Scholar
  10. 10.
    LeFranc, M.-P., Forster, A., and Rabbitts, T.H. Genetic polymorphism and exon changes of the constant regions of the human T-cell rearranging gene y. Proc. Natl. Acad. Sci. USA 83: 9596–9600 (1986b).PubMedCrossRefGoogle Scholar
  11. 11.
    Littman, D.R., Newton, M., Crommie, D., Ang, S.-L., Seidman, J.G., Gettner, S.N., and Weiss, A. Characterization of an expressed CD3- associated Ti y -chain reveals Cy domain polymorphism. Nature 326: 85–88 (1987).PubMedCrossRefGoogle Scholar
  12. 12.
    Pelicci, P.G., Subar, M., Weiss, A., Dalla-Favera, R., and Littman, D.R. Molecular diversity of the human T-gamma constant region genes. Science 237: 1051–1055 (1987).PubMedCrossRefGoogle Scholar
  13. 13.
    Quertermous, T., Murre, C., Dialynas, D., Duby, A.D., Strominger, J.L., Waldman, T.A., and Seidman, J.G. Human T-cell y chain genes: Organization, diversity, and rearrangement. Science 231: 252–255 (1986).PubMedCrossRefGoogle Scholar
  14. 14.
    Saito, H., Kranz, D.M., Takagaki, Y., Hayday, A.C., Eisen, H.N., and Tonegawa, S. Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature 309: 757–762 (1984).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Michael B. Brenner
    • 1
    • 2
  • Frans Hochstenbach
    • 1
  • Hamid Band
    • 1
  • Christina Parker
    • 1
  • Joanne McLean
    • 1
  • Shingo Hata
    • 3
  • Michael Krangel
    • 3
  1. 1.Laboratory of Immunochemistry, Dana Farber Cancer InstituteHarvard Medical SchoolBostonUSA
  2. 2.Department of Rheumatology and Immunology, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  3. 3.Division of Tumor Virology, Dana Farber Cancer InstituteHarvard Medical SchoolBostonUSA

Personalised recommendations