Lipids in Parenteral Nutrition: Benefits in Critically Ill Patients?
Currently, total parenteral nutrition (TPN) is used for nutritional support in a wide variety of patients when the enteral route cannot be used. Over the past 30 years, long-chain triglycerides (LCT) derived from soybean or safflower oil have been the source of lipid emulsions for parenteral nutrition. Traditionally, lipid emulsions are included in parenteral nutrition regimes both as part of energy supply and as a source of essential fatty acids. It has become obvious during the last two decades that the amount and type of long-chain fatty acids consumed in the diet can profoundly influence biological responses. Therefore, efforts to further develop and optimize lipid emulsions have focused on replacing part of the LCT by medium-chain triglycerides (MCT). As a result, the physical MCT/LCT mixture is a well proven concept in TPN regimes. Mixed triglyceride molecules obtained by interesterifying MCT and LCT — so called structured triglycerides — are the latest result of this chain of development.
KeywordsParenteral Nutrition Total Parenteral Nutrition Lipid Emulsion Structure Triglyceride Parenteral Nutrition Regime
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