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Use of Dopaminergic Agonists for Renal Protection in the ICU

  • P. T. Murray
Conference paper

Abstract

The mortality of acute renal failure is commonly 50–80% in the intensive care unit (ICU), and has not declined significantly since the initial marked benefit of acute dialysis therapy, despite numerous advances in renal replacement technologies and critical care over several decades. Most acute renal failure in ICU patients is caused by either prerenal azotemia (reversible renal insufficiency due to renal hypoperfusion) or acute tubular necrosis (ATN). ATN results from a variety of ischemic and nephrotoxic insults, often in additive or synergistic combination. Because renal hypoperfusion plays a role in the pathogenesis of prerenal azotemia and ATN, ‘lowdose’ dopamine dopamine is commonly used as a renal vasodilator aiming to prevent or treat acute renal failure in the ICU. This chapter reviews the use of dopamine and a novel dopaminergic agonist called fenoldopam for renal protection in the ICU.

Keywords

Intensive Care Unit Acute Renal Failure Intensive Care Unit Patient Renal Blood Flow Acute Tubular Necrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag Berlin Heidelberg 2003

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  • P. T. Murray

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