Expiratory Flow Limitation in Mechanically Ventilated Patients

  • A. Koutsoukou
  • C. Roussos
  • J. Milic-Emili

Abstract

The highest pulmonary ventilation that a subject can achieve is ultimately limited by the highest flow rates that can be generated. Most normal subjects and endurance-trained athletes do not exhibit expiratory flow limitation even during maximal exercise [1, 2]. In contrast, patients with chronic obstructive pulmonary disease (COPD) may exhibit expiratory flow limitation even at rest, as first reported by Hyatt [1]. This is based on the observation that, even at rest, many patients with severe COPD often breathe tidally along their maximal expiratory flow-volume (MEFV) curve (Fig. 1) [3]. The presence of expiratory flow limitation during tidal breathing promotes dynamic hyperinflation with a concurrent increase in inspiratory work, functional impairment of inspiratory muscles, and adverse effects on hemodynamics and dyspnea [4, 5]. It also plays a central role in causing acute ventilatory failure.

Keywords

Chronic Obstructive Pulmonary Disease Acute Respiratory Distress Syndrome Acute Respiratory Distress Syndrome Patient Ventilator Induce Lung Injury Peripheral Airway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • A. Koutsoukou
  • C. Roussos
  • J. Milic-Emili

There are no affiliations available

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