Severe Thrombotic Microangiopathy in Critically Ill Patients

  • F. Pene
  • Y. E. Claessens
  • J. P. Mira
Conference paper

Abstract

Thrombotic microangiopathies (TMA) are uncommon multisystemic microvascular occlusive diseases combining various stages of hematological, renal, and neurological disorders and characterized by a classical pentad: fever, peripheral thrombocytopenia, microangiopathic hemolytic anemia, acute renal failure, and neurological abnormalities. Treatment with exogenous plasma, either through plasma exchange or plasma infusion, has dramatically improved the outcome of the disease. However, most severe patients require monitoring and support in the intensive care unit (ICU) for organ failures, mainly renal, and neurological disorders. This chapter provides recent insights into the pathophysiology of the disease and focuses on treatment management and prognosis of severe TMA.

Keywords

Plasma Exchange Hemolytic Uremic Syndrome Thrombotic Thrombocytopenic Purpura Thrombotic Microangiopathy Plasma Infusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • F. Pene
  • Y. E. Claessens
  • J. P. Mira

There are no affiliations available

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